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Growth hormone receptor binds Lyn
Stable Identifier
R-HSA-1168456
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
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Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Growth hormone receptor signaling (Homo sapiens)
Growth hormone receptor binds Lyn (Homo sapiens)
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There is accumulating evidence that GH signalling utilises a Src family tyrosine kinase independently of JAK2, and that this is linked to activation of extracellular regulated kinases (ERKs) 1 and 2 (p44/42 MAPK). The relative strengths of these signaling pathways probably depends on cell type and may be mediated by conformational changes that are a consequence of ligand binding (Rowlinson et al. 2007). In NIH-3T3 cells GH activated c-Src, which in turn activated ERK1/2 via a pathway involving the activation of the Ras-like small GTPases RalA and RalB, leading to Elk-1 mediated transcription (Zhu et al. 2002). JAK2 and c-Src were both found to activate the Ras-like small GTPases Rap1 and Rap2 which inhibit RalA mediated activation of ERK1/2 (Ling et al. 2003). Src kinase inhibition was found to block ERK activation by GH. The major contributing kinase was identified as Lyn, which was found to co-immunoprecipitate with GHR and bind to the proximal 150 residues of the cytoplasmic domain (Rowlinson et al. 2007).
Participants
Input
Growth Hormone: Growth Hormone Receptor-JAK2 dimer [plasma membrane]
(Homo sapiens)
LYN [cytosol]
(Homo sapiens)
Output
Growth Hormone:Growth Hormone Receptor-JAK2 dimer:LYN [plasma membrane]
(Homo sapiens)
Participates
as an event of
Growth hormone receptor signaling (Homo sapiens)
Inferred From
Growth hormone receptor binds Lyn (Mus musculus)
Authored
Jupe, S (2010-10-14)
Reviewed
Herington, AC (2011-06-13)
Waters, MJ (2011-06-23)
Created
Jupe, S (2010-12-22)
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