Downstream signaling events of B Cell Receptor (BCR)

Stable Identifier
R-HSA-1168372
Type
Pathway
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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Downstream signaling events of B Cell Receptor (BCR)
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Second messengers (calcium, diacylglycerol, inositol 1,4,5-trisphosphate, and phosphatidyinositol 3,4,5-trisphosphate) trigger signaling pathways: NF-kappaB is activated via protein kinase C beta, RAS via RasGRP proteins, NF-AT via calcineurin, and AKT via PDK1 (reviewed in Shinohara and Kurosaki 2009, Stone 2006).
Literature References
PubMed ID Title Journal Year
17052215 Regulation of Ras in lymphocytes: get a GRP

Stone, JC

Biochem Soc Trans 2006
19909372 Comprehending the complex connection between PKCbeta, TAK1, and IKK in BCR signaling

Shinohara, H, Kurosaki, T

Immunol Rev 2009
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Authored
May, B  (2010-12-09)
Reviewed
Wienands, J  (2012-02-12)
Created
May, B  (2010-12-19)
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