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p-RASGRP1,3:DAG [plasma membrane]
Stable Identifier
R-HSA-1168369
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Phosphorylated RasGRP1,3:Diacylglycerol, Phosphorylated RasGRP3:Diacylglycerol and phosphorylated RasGRP1:Diacylglycerol
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Activation of RAS in B cells (Homo sapiens)
RasGRP1 and RasGRP3 binds diacylglycerol and is phosphorylated (Homo sapiens)
p-RASGRP1,3:DAG [plasma membrane] (Homo sapiens)
p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Homo sapiens)
p-RASGRP1,3:DAG [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
p-RASGRP1,3:DAG [plasma membrane] (Homo sapiens)
General
RasGRP3 binds diacylglycerol via its C1 domain.
Literature References
PubMed ID
Title
Journal
Year
11221888
Phorbol esters modulate the Ras exchange factor RasGRP3
Stone, JC
,
Garfield, SH
,
Kung, JW
,
Blumberg, PM
,
Lorenzo, PS
,
Bottorff, DA
Cancer Res
2001
Participants
components
DAG [plasma membrane]
p-RASGRP1,3 [plasma membrane]
(Homo sapiens)
Participates
as an output of
RasGRP1 and RasGRP3 binds diacylglycerol and is phosphorylated (Homo sapiens)
as a member of
RAS GEFs [plasma membrane] (Homo sapiens)
Inferred To
p-RASGRP1,3:DAG [plasma membrane]
(Bos taurus)
p-RASGRP1,3:DAG [plasma membrane]
(Caenorhabditis elegans)
p-RASGRP1,3:DAG [plasma membrane]
(Canis familiaris)
p-RASGRP1,3:DAG [plasma membrane]
(Danio rerio)
p-RASGRP1,3:DAG [plasma membrane]
(Gallus gallus)
p-RASGRP1,3:DAG [plasma membrane]
(Mus musculus)
p-RASGRP1,3:DAG [plasma membrane]
(Rattus norvegicus)
p-RASGRP1,3:DAG [plasma membrane]
(Sus scrofa)
p-RASGRP1,3:DAG [plasma membrane]
(Xenopus tropicalis)
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