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p-T133-RASGRP3 [plasma membrane]
Stable Identifier
R-HSA-1168362
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Ras guanyl-releasing protein 3 phosphorylated at Threonine-133, GRP3_HUMAN, RASGRP3, CalDAG-GEFIII
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Activation of RAS in B cells (Homo sapiens)
RasGRP1 and RasGRP3 binds diacylglycerol and is phosphorylated (Homo sapiens)
p-RASGRP1,3:DAG [plasma membrane] (Homo sapiens)
p-RASGRP1,3 [plasma membrane] (Homo sapiens)
p-T133-RASGRP3 [plasma membrane] (Homo sapiens)
p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Homo sapiens)
p-RASGRP1,3 [plasma membrane] (Homo sapiens)
p-T133-RASGRP3 [plasma membrane] (Homo sapiens)
p-RASGRP1,3:DAG [plasma membrane] (Homo sapiens)
p-RASGRP1,3 [plasma membrane] (Homo sapiens)
p-T133-RASGRP3 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
p-RASGRP1,3:DAG [plasma membrane] (Homo sapiens)
p-RASGRP1,3 [plasma membrane] (Homo sapiens)
p-T133-RASGRP3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IV61 RASGRP3
Gene Names
RASGRP3, GRP3, KIAA0846
Chain
chain:1-690
Reference Genes
BioGPS Gene:25780 RASGRP3
COSMIC (genes):RASGRP3 RASGRP3
CTD Gene:25780 RASGRP3
dbSNP Gene:25780 RASGRP3
ENSEMBL:ENSG00000152689 RASGRP3
HGNC:14545 RASGRP3
KEGG:hsa:25780 RASGRP3
Monarch:25780 RASGRP3
NCBI Gene:25780 RASGRP3
OMIM:609531 RASGRP3
UCSC:Q8IV61 RASGRP3
Reference Transcript
RefSeq:XM_017003760.1 RASGRP3
RefSeq:XM_017003761.1 RASGRP3
RefSeq:XM_017003763.1 RASGRP3
RefSeq:XM_005264246.3 RASGRP3
RefSeq:NM_170672.2 RASGRP3
RefSeq:XM_011532747.2 RASGRP3
RefSeq:XM_011532746.2 RASGRP3
RefSeq:NM_015376.2 RASGRP3
RefSeq:XM_011532748.2 RASGRP3
RefSeq:XM_017003759.1 RASGRP3
RefSeq:NM_001139488.1 RASGRP3
RefSeq:XM_017003762.1 RASGRP3
Other Identifiers
11739918_a_at
11740140_a_at
16878994
205801_PM_s_at
205801_s_at
244526_PM_at
244526_at
2476674
2476675
2476676
2476680
2476681
2476689
2476690
2476691
2476692
2476694
2476695
2476696
2476697
2476698
2476699
2476700
2476703
2476704
2476705
2476706
2476707
2476708
2476709
2476710
2476711
2476712
2476715
2476716
2476717
2476718
2476719
2476720
2476722
2476724
2476725
2476726
2476734
2476735
2476736
2476737
2476738
2476740
2476741
2476742
2476750
2476752
25780
34748_at
51323_at
52707_at
62375_at
8041422
A_14_P121516
A_14_P129939
A_24_P54390
A_33_P3365582
GE611363
GE620730
GE62258
GE787177
GO:0000165
GO:0005085
GO:0005096
GO:0005509
GO:0005515
GO:0005737
GO:0005886
GO:0007264
GO:0007265
GO:0008289
GO:0019900
GO:0019992
GO:0031267
GO:0032045
GO:0046872
GO:0048471
GO:0098772
HMNXSV003021668
Hs.147800.0.A1_3p_at
ILMN_1727045
PH_hs_0002121
TC02000221.hg
g7662333_3p_s_at
Participates
as a member of
p-RASGRP1,3 [plasma membrane] (Homo sapiens)
Other forms of this molecule
RASGRP3 [cytosol]
Inferred To
phospho-rgef-1 [plasma membrane]
(Caenorhabditis elegans)
phospho-Rasgrp3 [plasma membrane]
(Mus musculus)
phospho-Rasgrp3 [plasma membrane]
(Rattus norvegicus)
phospho-RASGRP3 [plasma membrane]
(Bos taurus)
phospho-RASGRP3 [plasma membrane]
(Canis familiaris)
phospho-RASGRP3 [plasma membrane]
(Gallus gallus)
phospho-p-T133-RASGRP3 [plasma membrane]
(Sus scrofa)
phospho-rasgrp3 [plasma membrane]
(Danio rerio)
phospho-rasgrp3 [plasma membrane]
(Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-threonine at 133
Coordinate
133
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
XP_011531050.2
,
NP_733772.1
,
XP_016859251.1
,
XP_016859250.1
,
NP_001132960.1
,
XP_005264303.1
,
XP_016859249.1
,
XP_016859252.1
,
XP_016859248.1
,
XP_011531048.1
,
NP_056191.1
,
XP_011531049.1
OpenTargets
ENSG00000152689
ENSEMBL
ENST00000402538
,
ENSP00000383917
,
ENSP00000385886
,
ENSP00000384192
,
ENST00000403687
,
ENST00000407811
,
ENSG00000152689
HPA
ENSG00000152689-RASGRP3
GeneCards
RASGRP3
ZINC - Substances
GRP3_HUMAN
ZINC target
Q8IV61
PRO
Q8IV61
Pharos - Targets
Q8IV61
ZINC - Predictions - Purchasable
GRP3_HUMAN
HMDB Protein
HMDBP10973
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P38206 RFT1
1
Rft1 [endoplasmic reticulum membrane]
(R-SCE-449768)
0.556
3
UniProt:Q8NBQ5 HSD17B11
1
HSD17B11 [cytosol]
(R-HSA-5693370)
0.556
3
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