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LEFTY2(22-366) [extracellular region]
Stable Identifier
R-HSA-114708
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
TGF-beta 4, Transforming growth factor beta 4 precursor, Endometrial bleeding-associated factor, Left-right determination factor A, Lefty-A protein, LEFTY2
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Signaling by NODAL (Homo sapiens)
Regulation of signaling by NODAL (Homo sapiens)
LEFTY binds NODAL (Homo sapiens)
LEFTY1,2 [extracellular region] (Homo sapiens)
LEFTY2(22-366) [extracellular region] (Homo sapiens)
LEFTY1,2:NODAL [extracellular region] (Homo sapiens)
LEFTY1,2 [extracellular region] (Homo sapiens)
LEFTY2(22-366) [extracellular region] (Homo sapiens)
LEFTY binds the EGF-CFC coreceptor in the NODAL receptor (Homo sapiens)
LEFTY1,2 [extracellular region] (Homo sapiens)
LEFTY2(22-366) [extracellular region] (Homo sapiens)
LEFTY1,2:NODAL Receptor [plasma membrane] (Homo sapiens)
LEFTY1,2 [extracellular region] (Homo sapiens)
LEFTY2(22-366) [extracellular region] (Homo sapiens)
The NODAL Receptor binds NODAL ligands (Homo sapiens)
LEFTY1,2 [extracellular region] (Homo sapiens)
LEFTY2(22-366) [extracellular region] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Exocytosis of platelet alpha granule contents (Homo sapiens)
Platelet alpha granule contents [extracellular region] (Homo sapiens)
LEFTY2(22-366) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00292 LEFTY2
Gene Names
LEFTY2, EBAF, LEFTA, LEFTYA, TGFB4, PSEC0024
Chain
signal peptide:1-21, propeptide:22-76, chain:77-366
Reference Genes
BioGPS Gene:7044 LEFTY2
COSMIC (genes):LEFTY2 LEFTY2
CTD Gene:7044 LEFTY2
dbSNP Gene:7044 LEFTY2
ENSEMBL:ENSG00000143768 LEFTY2
HGNC:3122 LEFTY2
KEGG:hsa:7044 LEFTY2
Monarch:7044 LEFTY2
NCBI Gene:7044 LEFTY2
OMIM:601877 LEFTY2
UCSC:O00292 LEFTY2
Reference Transcript
RefSeq:NM_003240.4 LEFTY2
RefSeq:NM_001172425.2 LEFTY2
Other Identifiers
11751344_a_at
11754665_x_at
11756110_a_at
16699998
206012_PM_at
206012_at
2458582
2458584
2458585
2458586
2458630
2458631
2458632
2458633
2458634
2458635
2458636
2458637
2458639
2458640
2458641
39325_at
7044
7924682
A_23_P137573
GE527396
GE59474
GO:0005125
GO:0005160
GO:0005576
GO:0005615
GO:0007165
GO:0008083
GO:0009948
GO:0030312
GO:0031012
GO:0031093
GO:0048018
GO:0062023
GO:0098772
HMNXSV003040696
HMNXSV003045219
ILMN_1781256
PH_hs_0002213
TC01003894.hg
TC01003895.hg
U81523_at
g4503440_3p_at
g4503440_3p_s_at
p668
Participates
as a member of
Platelet alpha granule contents [extracellular region] (Homo sapiens)
LEFTY1,2 [extracellular region] (Homo sapiens)
Other forms of this molecule
LEFTY2 [platelet alpha granule lumen]
Inferred To
LEFTY2 [extracellular region]
(Bos taurus)
LEFTY2 [extracellular region]
(Sus scrofa)
Homologues of LEFTY2(22-366) [extracellular region]
(Bos taurus)
Homologues of LEFTY2(22-366) [extracellular region]
(Caenorhabditis elegans)
Homologues of LEFTY2(22-366) [extracellular region]
(Canis familiaris)
Homologues of LEFTY2(22-366) [extracellular region]
(Danio rerio)
Homologues of LEFTY2(22-366) [extracellular region]
(Drosophila melanogaster)
Homologues of LEFTY2(22-366) [extracellular region]
(Mus musculus)
Homologues of LEFTY2(22-366) [extracellular region]
(Rattus norvegicus)
Homologues of LEFTY2(22-366) [extracellular region]
(Sus scrofa)
LOC490387 [extracellular region]
(Canis familiaris)
LEFTY2(22-366) [extracellular region]
(Gallus gallus)
LEFTY1 [extracellular region]
(Canis familiaris)
unc-129 [extracellular region]
(Caenorhabditis elegans)
lft1 [extracellular region]
(Danio rerio)
lft2 [extracellular region]
(Danio rerio)
mav [extracellular region]
(Drosophila melanogaster)
lefty1 [extracellular region]
(Xenopus tropicalis)
Lefty1 [extracellular region]
(Mus musculus)
Lefty1 [extracellular region]
(Rattus norvegicus)
Lefty2 [extracellular region]
(Mus musculus)
Lefty2 [extracellular region]
(Rattus norvegicus)
dbl-1 [extracellular region]
(Caenorhabditis elegans)
daf-7 [extracellular region]
(Caenorhabditis elegans)
LOC100524517 [extracellular region]
(Sus scrofa)
dpp [extracellular region]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001165896.1
,
NP_003231.2
ENSEMBL
ENST00000420304
,
ENST00000366820
,
ENSP00000388009
,
ENSP00000355785
,
ENSG00000143768
OpenTargets
ENSG00000143768
GeneCards
LEFTY2
HPA
ENSG00000143768-LEFTY2
PRO
O00292
Pharos - Targets
O00292
GlyGen
O00292
Orphanet
LEFTY2
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