PLC gamma 2-mediated PIP2 hydrolysis

Stable Identifier
R-HSA-114689
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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PLC gamma 2-mediated PIP2 hydrolysis
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
At the beginning of this reaction, 1 molecule of '1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate' is present. At the end of this reaction, 1 molecule of '1D-myo-Inositol 1,4,5-trisphosphate', and 1 molecule of '1,2-Diacylglycerol' are present.

This reaction is mediated by the 'phospholipase C activity' of 'Phosphorylated phospholipase C gamma 2'.
Literature References
PubMed ID Title Journal Year
2841328 Purification and characterization of membrane-bound phospholipase C specific for phosphoinositides from human platelets

Banno, Y, Yada, Y, Nozawa, Y

J Biol Chem 1988
Participants
Input
Output
Participates
as an event of
Catalyst Activity

C-type glycerophospholipase activity of p-PLCG2 [plasma membrane]

Physical Entity
p-PLCG2 [plasma membrane] (Homo sapiens)
Activity
C-type glycerophospholipase activity (GO:0004629)
This event is regulated
Positively by
Regulator
p-Y7-CLEC1B dimer:PDPN:SYK [plasma membrane] (Homo sapiens)
Orthologous Events
PLC gamma 2-mediated PIP2 hydrolysis (Bos taurus)
PLC gamma 2-mediated PIP2 hydrolysis (Caenorhabditis elegans)
PLC gamma 2-mediated PIP2 hydrolysis (Canis familiaris)
PLC gamma 2-mediated PIP2 hydrolysis (Dictyostelium discoideum)
PLC gamma 2-mediated PIP2 hydrolysis (Drosophila melanogaster)
PLC gamma 2-mediated PIP2 hydrolysis (Gallus gallus)
PLC gamma 2-mediated PIP2 hydrolysis (Mus musculus)
PLC gamma 2-mediated PIP2 hydrolysis (Plasmodium falciparum)
PLC gamma 2-mediated PIP2 hydrolysis (Rattus norvegicus)
PLC gamma 2-mediated PIP2 hydrolysis (Saccharomyces cerevisiae)
PLC gamma 2-mediated PIP2 hydrolysis (Schizosaccharomyces pombe)
PLC gamma 2-mediated PIP2 hydrolysis (Sus scrofa)
PLC gamma 2-mediated PIP2 hydrolysis (Xenopus tropicalis)
Cross References
RHEA
Created
de Bono, B  (2004-09-25)
Pace, NP  (2004-09-25)
Farndale, R  (2004-09-25)
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