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PLCG2 [plasma membrane]
Stable Identifier
R-HSA-114601
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Phospholipase C gamma 2
Icon
Locations in the PathwayBrowser for interactor UniProt:O95997 PTTG1
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GPVI-mediated activation cascade (Homo sapiens)
SLP-76 stimulates PLC gamma 2 (Homo sapiens)
PLCG2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16885 PLCG2
Gene Names
PLCG2
Chain
chain:1-1265
Reference Genes
BioGPS Gene:5336 PLCG2
COSMIC (genes):PLCG2 PLCG2
CTD Gene:5336 PLCG2
dbSNP Gene:5336 PLCG2
ENSEMBL:ENSG00000197943 PLCG2
HGNC:9066 PLCG2
KEGG:hsa:5336 PLCG2
Monarch:5336 PLCG2
NCBI Gene:5336 PLCG2
OMIM:600220 PLCG2
UCSC:P16885 PLCG2
Reference Transcript
RefSeq:NM_002661.4 PLCG2
Other Identifiers
105369213
1085_s_at
11720244_at
1557993_PM_at
1557993_at
1563263_PM_at
1563263_at
16821326
16821330
16821365
204613_PM_at
204613_at
230917_PM_at
230917_at
3670919
3670920
3670921
3670922
3670923
3670924
3670925
3670926
3670927
3670928
3670935
3670937
3670938
3670941
3670942
3670943
3670948
3670949
3670950
3670955
3670956
3670966
3670968
3670973
3670975
3670976
3670978
3670979
3670980
3670985
3670986
3670990
3670991
3670992
3670993
3670994
3670996
3670997
3670998
3670999
3671000
3671004
3671005
3671006
3671007
3671008
3671009
3671011
3671012
3671013
3671014
3671016
3671017
3671018
3671019
3671020
3671021
3671026
3671029
3671030
3671033
3671034
3671035
3671036
3671037
3671038
3671039
3671040
3671042
3671048
3671049
3671050
3671051
3671052
3671053
3671054
3671055
3671056
3671057
3671065
3671066
3671068
37180_at
46931_at
5336
71846_at
7997453
7997489
86167_at
A_14_P104760
A_14_P126195
A_21_P0008876
A_23_P106675
A_32_P52632
GE476829
GE57955
GE61863
GE632307
GO:0001775
GO:0001784
GO:0001878
GO:0002092
GO:0002223
GO:0002224
GO:0002281
GO:0002316
GO:0002376
GO:0002732
GO:0003824
GO:0004435
GO:0004620
GO:0004629
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0006355
GO:0006629
GO:0006661
GO:0007165
GO:0008081
GO:0009395
GO:0010468
GO:0010628
GO:0010634
GO:0012501
GO:0016020
GO:0016042
GO:0016055
GO:0016787
GO:0019216
GO:0019722
GO:0019901
GO:0030154
GO:0030168
GO:0030183
GO:0031663
GO:0032481
GO:0032496
GO:0032587
GO:0032733
GO:0032735
GO:0032743
GO:0032747
GO:0032755
GO:0032760
GO:0032959
GO:0035556
GO:0038095
GO:0042113
GO:0043069
GO:0043122
GO:0043226
GO:0043410
GO:0045121
GO:0046488
GO:0048015
GO:0048471
GO:0048678
GO:0050731
GO:0050850
GO:0050852
GO:0050853
GO:0051091
GO:0051092
GO:0051209
GO:0055085
GO:0060100
GO:0060907
GO:0061760
GO:0070062
GO:0070884
GO:0071277
GO:0071396
GO:0097110
GO:0097708
GO:0098542
GO:0140031
GO:0150078
GO:1900227
GO:1902808
GO:1903428
GO:1903721
GO:1990782
GO:1990858
HMNXSV003012305
HMNXSV003023910
HMNXSV003031254
HMNXSV003035070
HMNXSV003039416
HMNXSV003040103
Hs.6179.2.A1_3p_at
Hs.6179.2.A1_3p_x_at
Hs2.382891.1.S1_3p_at
Hs2.382891.1.S1_3p_x_at
Hs2.434339.1.S1_3p_s_at
ILMN_1815719
M37238_s_at
PH_hs_0019237
PH_hs_0026742
RNA144108|snRNA_61_317
TC16000642.hg
TC16000643.hg
TC16000644.hg
TC16001661.hg
TC16001662.hg
TC16001663.hg
g4505870_3p_at
p6539
p6540
p6541
p6542
p6543
p6544
Participates
as a component of
PLCG2:Ca2+ [plasma membrane] (Homo sapiens)
as an input of
SLP-76 stimulates PLC gamma 2 (Homo sapiens)
Other forms of this molecule
p-PLCG2 [plasma membrane]
p-Y753,Y759,Y1217-PLCG2 [plasma membrane]
PLCG2 [cytosol]
p-4Y-PLCG2 [plasma membrane]
p-Y753,Y759-PLCG2 [plasma membrane]
p-Y753,Y759-PLCG2 [cytosol]
p-Y-PLCG2 [cytosol]
Inferred To
plcg2 [plasma membrane]
(Xenopus tropicalis)
sl [plasma membrane]
(Drosophila melanogaster)
PLCG2 [plasma membrane]
(Bos taurus)
PLCG2 [plasma membrane]
(Canis familiaris)
PLCG2 [plasma membrane]
(Dictyostelium discoideum)
PLCG2 [plasma membrane]
(Gallus gallus)
PLCG2 [plasma membrane]
(Plasmodium falciparum)
PLCG2 [plasma membrane]
(Saccharomyces cerevisiae)
PLCG2 [plasma membrane]
(Schizosaccharomyces pombe)
PLCG2 [plasma membrane]
(Sus scrofa)
Plcg2 [plasma membrane]
(Mus musculus)
Plcg2 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_002652.2
Guide to Pharmacology - Targets
1408
OpenTargets
ENSG00000197943
ENSEMBL
ENST00000564138
,
ENSP00000482457
ZINC - Substances
PLCG2_HUMAN
ZINC target
P16885
PRO
P16885
GlyGen
P16885
PDB
2W2X
,
2W2W
,
2K2J
HPA
ENSG00000197943-PLCG2
Pharos - Targets
P16885
Orphanet
PLCG2
ZINC - Predictions - Purchasable
PLCG2_HUMAN
HMDB Protein
HMDBP00230
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.793
6
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.571
3
UniProt:P27986 PIK3R1
16
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
0.536
2
UniProt:O14796 SH2D1B
1
SH2D1B [cytosol]
(R-HSA-5685187)
0.525
2
UniProt:O43242 PSMD3
5
PSMD3 [cytosol]
(R-HSA-68798)
PSMD3 [nucleoplasm]
(R-HSA-174328)
PSMD3 [secretory granule lumen]
(R-HSA-6800873)
PSMD3 [extracellular region]
(R-HSA-6806443)
PSMD3 [ficolin-1-rich granule lumen]
(R-HSA-6800408)
0.508
2
UniProt:O95073-2 FSBP
0.508
2
UniProt:P78381 SLC35A2
6
SLC35A2 F324Lfs*25 [Golgi membrane]
(R-HSA-5652088)
SLC35A2 G8Sfs*9 [Golgi membrane]
(R-HSA-5652107)
SLC35A2 V331I [Golgi membrane]
(R-HSA-5652093)
SLC35A2 Y145Pfs*76 [Golgi membrane]
(R-HSA-5652114)
SLC35A2 M1? [Golgi membrane]
(R-HSA-5652101)
SLC35A2 [Golgi membrane]
(R-HSA-735686)
0.499
2
UniProt:O95997 PTTG1
2
K11polyUb-PTTG1 [cytosol]
(R-HSA-3095943)
PTTG1 [cytosol]
(R-HSA-174190)
0.488
2
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.488
2
UniProt:P19419 ELK1
2
ELK1 [nucleoplasm]
(R-HSA-3009346)
p-4S,T336-ELK1 [nucleoplasm]
(R-HSA-3009350)
0.488
2
UniProt:Q68G74 LHX8
0.488
2
UniProt:P10809 HSPD1
6
HSPD1(1-573) [cytosol]
(R-HSA-1267989)
HSPD1(1-573) [mitochondrial intermembrane space]
(R-HSA-1267963)
HSPD1(1-26) [mitochondrial matrix]
(R-HSA-8986171)
HSPD1(1-573) [mitochondrial inner membrane]
(R-HSA-1299442)
HSPD1 [mitochondrial inner membrane]
(R-HSA-1299455)
HSPD1 [mitochondrial matrix]
(R-HSA-1299448)
0.488
2
UniProt:Q99645 EPYC
0.488
2
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