Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3

Stable Identifier
R-HSA-114419
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3
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The linker region preceding BIR2 of XIAP is responsible for the inhibition of caspase-3 and -7, which is further stabilized by interaction with the BIR2 domain itself (Scott et al. 2005). Binding of DIABLO (SMAC) to BIR2 domain of XIAP can destabillize the XIAP:CASP3 interaction promoting the liberation of active caspase-3 from its complex with XIAP (Kashkar et al. 2003). Furthermore, SMAC (DIABLO) interacted with the BIR3 and then BIR2 domains of XIAP sequentially, and such dynamic interaction cooperatively neutralized inhibition of caspase-3 by the linker region of XIAP (Gao Z et al. 2007).
Literature References
PubMed ID Title Journal Year
12874265 XIAP-mediated caspase inhibition in Hodgkin's lymphoma-derived B cells

Kashkar, H, Haefs, C, Shin, H, Hamilton-Dutoit, SJ, Salvesen, GS, Kronke, M, Jurgensmeier, JM

J. Exp. Med. 2003
Participants
Input
Output
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as an event of
Inferred From
Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Homo sapiens)
Authored
Alnemri, E  (2004-02-17)
Reviewed
Matthews, L  (2018-11-05)
Created
Alnemri, E  (2004-02-17)
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