Sequestration of tBID by BCL-2

Stable Identifier
R-HSA-114352
Type
Reaction [binding]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
ReviewStatus
5/5
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Sequestration of tBID by BCL-2
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BCL2 binds tBID and inhibits BID-induced cytochrome C release and apoptosis (Yi et al. 2003).
Literature References
PubMed ID Title Journal Year
12624108 Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed

Dong, Z, Yin, XM, Yi, X

J Biol Chem 2003
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
negative regulation of apoptotic process (0043066)
Orthologous Events
Sequestration of tBID by BCL-2 (Bos taurus)
Sequestration of tBID by BCL-2 (Canis familiaris)
Sequestration of tBID by BCL-2 (Danio rerio)
Sequestration of tBID by BCL-2 (Gallus gallus)
Sequestration of tBID by BCL-2 (Mus musculus)
Sequestration of tBID by BCL-2 (Sus scrofa)
Sequestration of tBID by BCL-2 (Xenopus tropicalis)
Created
Hardwick, JM  (2004-08-09)
Tsujimoto, Y  (2004-08-09)
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