Release of SMAC (DIABLO) from mitochondria

Stable Identifier
R-HSA-114307
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Permeabilization of the outer mitochondrial membrane by pro-apoptotic BCL2 family members BAK and BAX allows release of direct IAP-binding protein with low pI (DIABLO, also known as SMAC) from the mitochondrial intermembrane space into the cytosol (Du C et al, 2000; Arnoult D et al. 2003). When released from mitochondria, DIABLO acts as a natural antagonist of inhibitor of apoptosis proteins (IAPs). DIABLO antagonistic activity is based on its N-terminal tetrapeptide (AVPI) that binds baculoviral IAP repeat (BIR) domains of IAPs, releasing their inhibitory effects on both initiator and effector caspases, thus promoting cell death (Du C et al. 2000; Gao Z et al. 2007). Binding of DIABLO (SMAC) to survivin leads to the inhibition of apoptosis (Song Z et al. 2003).

Literature References
Participants
Participant Of
This event is regulated
Orthologous Events
Reviewed
Created