SMAC binds XIAP:Caspase-3

Stable Identifier
R-HSA-114306
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SMAC binds XIAP:Caspase-3
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Binding of a dimeric SMAC (DIABLO) N‑terminal peptide with the BIR2 domain of XIAP effectively antagonizes inhibition of caspase‑3 by XIAP (Wu G et al. 2000; Chai J et al. 2000). SMAC (DIABLO) interacts with the BIR3 and then BIR2 domains of XIAP sequentially, and such dynamic interaction cooperatively neutralizes inhibition of caspase‑3 by the linker region of XIAP (Gao Z et al. 2007).
Literature References
PubMed ID Title Journal Year
11257231 Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain

Huang, Y, Wu, H, Rich, RL, Park, YC, Myszka, DG, Segal, D

Cell 2001
9230442 X-linked IAP is a direct inhibitor of cell-death proteases.

Reed, JC, Deveraux, QL, Takahashi, R, Salvesen, GS

Nature 1997
14960576 Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells.

Du, C, Yang, QH

J Biol Chem 2004
Participants
Input
Output
Participates
as an event of
Inferred From
SMAC binds XIAP:Caspase-7 (Homo sapiens)
Reviewed
Matthews, L  (2018-11-05)
Created
Alnemri, E  (2004-02-17)
Cite Us!