SMAC binds XIAP:Caspase-3

Stable Identifier
R-HSA-114306
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Binding of a dimeric SMAC (DIABLO) N‑terminal peptide with the BIR2 domain of XIAP effectively antagonizes inhibition of caspase‑3 by XIAP (Wu G et al. 2000; Chai J et al. 2000). SMAC (DIABLO) interacts with the BIR3 and then BIR2 domains of XIAP sequentially, and such dynamic interaction cooperatively neutralizes inhibition of caspase‑3 by the linker region of XIAP (Gao Z et al. 2007).

Literature References
PubMed ID Title Journal Year
9230442 X-linked IAP is a direct inhibitor of cell-death proteases.

Deveraux, QL, Takahashi, R, Salvesen, GS, Reed, JC

Nature 1997
11257231 Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain

Huang, Y, Park, YC, Rich, RL, Segal, D, Myszka, DG, Wu, H

Cell 2001
14960576 Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells.

Yang, QH, Du, C

J Biol Chem 2004
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