SMAC binds XIAP:Caspase-3

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Binding of a dimeric SMAC (DIABLO) N‑terminal peptide with the BIR2 domain of XIAP effectively antagonizes inhibition of caspase‑3 by XIAP (Wu G et al. 2000; Chai J et al. 2000). SMAC (DIABLO) interacts with the BIR3 and then BIR2 domains of XIAP sequentially, and such dynamic interaction cooperatively neutralizes inhibition of caspase‑3 by the linker region of XIAP (Gao Z et al. 2007).

Literature References
PubMed ID Title Journal Year
11257231 Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain

Huang, Y, Wu, H, Rich, RL, Park, YC, Myszka, DG, Segal, D

Cell 2001
9230442 X-linked IAP is a direct inhibitor of cell-death proteases.

Reed, JC, Deveraux, QL, Takahashi, R, Salvesen, GS

Nature 1997
14960576 Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells.

Du, C, Yang, QH

J Biol Chem 2004
Inferred From
Cite Us!