Activation, translocation and oligomerization of BAX

Stable Identifier
R-HSA-114294
Type
Pathway
Species
Homo sapiens
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As a result of binding to Bid, Bax oligomerizes and integrates in the outer mitochondrial membrane, triggering cytochrome c release. Bax mitochondrial membrane insertion triggered by Bid may represent a key step in pathways leading to apoptosis (Eskes et al., 2000).

Literature References
PubMed ID Title Journal Year
12193163 Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein

Roucou, X, Montessuit, S, Antonsson, B, Martinou, JC

Biochem J 2002
11136736 Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells.

Antonsson, B, Montessuit, S, Sanchez, B, Martinou, JC

J Biol Chem 2001
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Event Information
Orthologous Events
Cross References
BioModels Database
Created