Reactome | Activation, translocation and oligomerization of BAX

Activation, translocation and oligomerization of BAX

Stable Identifier

R-HSA-114294

Type

Pathway

Species

Homo sapiens

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Activation, translocation and oligomerization of BAX

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As a result of binding to Bid, Bax oligomerizes and integrates in the outer mitochondrial membrane, triggering cytochrome c release. Bax mitochondrial membrane insertion triggered by Bid may represent a key step in pathways leading to apoptosis (Eskes et al., 2000).

Literature References

PubMed ID	Title	Journal	Year
12193163	Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein Roucou, X, Montessuit, S, Antonsson, B, Martinou, JC	Biochem J	2002
11136736	Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells. Antonsson, B, Montessuit, S, Sanchez, B, Martinou, JC	J Biol Chem	2001