Reactome | CCND3 [nucleoplasm]

CCND3 [nucleoplasm]

Stable Identifier

R-HSA-113835

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

G1/S-specific cyclin D3

Locations in the PathwayBrowser for interactor UniProt:Q9UBQ5 EIF3K

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External Reference Information

External Reference

UniProt:P30281 CCND3

Gene Names

CCND3

Chain

chain:1-292

Reference Genes

BioGPS Gene:896 CCND3

COSMIC (genes):CCND3 CCND3

CTD Gene:896 CCND3

dbSNP Gene:896 CCND3

ENSEMBL:ENSG00000112576 CCND3

HGNC:1585 CCND3

KEGG:hsa:896 CCND3

Monarch:896 CCND3

NCBI Gene:896 CCND3

OMIM:123834 CCND3

UCSC:P30281 CCND3

Reference Transcript

Other Identifiers

11754434_a_at

11762304_a_at

1794_at

1795_g_at

201700_PM_at

201700_at

2953867

2953868

2953869

2953870

2953871

2953872

2953873

2953874

2953875

2953876

2953877

2953878

2953879

2953880

2953888

2953902

2953903

2953904

2953905

8126371

83751_at

896

A_23_P214464

A_23_P361773

GE58142

GE885664

GO:0000082

GO:0000122

GO:0000307

GO:0001934

GO:0002376

GO:0003824

GO:0004693

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0006355

GO:0007165

GO:0016538

GO:0016740

GO:0019901

GO:0042098

GO:0042127

GO:0043226

GO:0045737

GO:0051301

GO:0051726

GO:0061575

GO:0097130

GO:0097133

GO:0098772

GO:0140096

GO:1900087

HMNXSV003039749

ILMN_1668721

M92287_at

PH_hs_0004752

g4502618_3p_at

Participates

as a component of

as an input of

MAPK6 binds CCND3 (Homo sapiens)

as a member of

CCND3,(CCND1,CCND2) [nucleoplasm] (Homo sapiens)

as a candidate of

Cyclin D [nucleoplasm] (Homo sapiens)

This entity regulates

Positively

Expression of FABP4 (aP2) (Homo sapiens)

Other forms of this molecule

CCND3 [cytosol]

Inferred To

ccndx [nucleoplasm] (Danio rerio)

ccnd2a [nucleoplasm] (Danio rerio)

CCND3 [nucleoplasm] (Bos taurus)

CCND3 [nucleoplasm] (Canis familiaris)

CCND3 [nucleoplasm] (Gallus gallus)

CCND3 [nucleoplasm] (Sus scrofa)

ccnd3 [nucleoplasm] (Danio rerio)

CycD [nucleoplasm] (Drosophila melanogaster)

Homologues of CCND3 [nucleoplasm] (Danio rerio)

Ccnd3 [nucleoplasm] (Mus musculus)

Ccnd3 [nucleoplasm] (Rattus norvegicus)

crs1 [nucleoplasm] (Schizosaccharomyces pombe)

cyd-1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001129489.1, NP_001274356.1, NP_001274363.1, NP_001751.1, NP_001129598.1, NP_001129597.1

OpenTargets

ENSG00000112576

ENSEMBL

ENSP00000426212, ENSP00000401595, ENST00000372991, ENST00000415497, ENSP00000362079, ENST00000372988, ENST00000414200, ENSP00000397545, ENSP00000362082, ENST00000616010, ENSP00000484424, ENST00000511642

HPA

ENSG00000112576-CCND3

ZINC - Substances

CCND3_HUMAN

ZINC target

P30281

PRO

P30281

Pharos - Targets

P30281

ZINC - Predictions - Purchasable

CCND3_HUMAN

PDB

7SJ3, 3G33

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11802 CDK4	3	p-T172-CDK4 [nucleoplasm] (R-HSA-113830) CDK4 [nucleoplasm] (R-HSA-113843) CDK4 [cytosol] (R-HSA-68330)	0.981	40
UniProt:Q00534 CDK6	3	p-T177-CDK6 [nucleoplasm] (R-HSA-69628) CDK6 [nucleoplasm] (R-HSA-141283) CDK6 [cytosol] (R-HSA-68336)	0.974	34
UniProt:P38936 CDKN1A	5	p-S130-CDKN1A [nucleoplasm] (R-HSA-187857) CDKN1A [nucleoplasm] (R-HSA-182585) CDKN1A [cytosol] (R-HSA-182512) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) p-T145-CDKN1A [cytosol] (R-HSA-198614)	0.965	29
UniProt:Q00535 CDK5	4	p-Y15-CDK5 [cytosol] (R-HSA-399809) CDK5 [cytosol] (R-HSA-180064) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) CDK5 [nucleoplasm] (R-HSA-8863586)	0.882	12
UniProt:Q9BT43 POLR3GL	2	POLR3GL [nucleoplasm] (R-HSA-1964458) POLR3GL [cytosol] (R-HSA-1964463)	0.781	9
UniProt:P46527 CDKN1B	8	p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.738	9
UniProt:P24941 CDK2	5	p-T160-CDK2 [nucleoplasm] (R-HSA-187967) CDK2 [nucleoplasm] (R-HSA-68365) CDK2 [cytosol] (R-HSA-157440) p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905)	0.725	7
UniProt:Q9UBQ5 EIF3K	1	EIF3K [cytosol] (R-HSA-72554)	0.691	4
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.666	5
UniProt:Q5VK71 AKAP8			0.646	6
UniProt:P06493 CDK1	11	p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) CDK1 [cytosol] (R-HSA-170075) CDK1 [nucleoplasm] (R-HSA-68889) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-Y4-CDK1 [cytosol] (R-HSA-9836187) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424)	0.643	4
UniProt:O94921 CDK14			0.616	5
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.556	3
UniProt:P29373 CRABP2	2	SUMO-K102-CRABP2 [nucleoplasm] (R-HSA-5334813) SUMO-K102-CRABP2 [cytosol] (R-HSA-5334798)	0.556	3
UniProt:P55273 CDKN2D	1	CDKN2D [cytosol] (R-HSA-182580)	0.556	3
UniProt:Q9BVG8-5 KIFC3			0.556	3
UniProt:Q8NEH6 MNS1			0.556	3
UniProt:Q00536-3 CDK16			0.556	3
UniProt:Q07002 CDK18			0.556	3
UniProt:Q9NWQ9 CN119			0.556	3
UniProt:Q8IYE1 CCD13			0.556	3
UniProt:Q00526 CDK3			0.556	5
UniProt:P08393 ICP0			0.543	3
UniProt:Q08999 RBL2	2	RBL2 [nucleoplasm] (R-HSA-389102) p-T401,S672,S1035-RBL2 [nucleoplasm] (R-HSA-1226084)	0.527	3
UniProt:Q92793 CREBBP	4	CREBBP [nucleoplasm] (R-HSA-193545) CREBBP [cytosol] (R-HSA-9756493) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877)	0.527	2
UniProt:P49918 CDKN1C	3	p-Y91-CDKN1C [cytosol] (R-HSA-8942606) CDKN1C [cytosol] (R-HSA-8941913) CDKN1C [nucleoplasm] (R-HSA-8948130)	0.527	3
UniProt:Q9Y337 KLK5	4	KLK5 [extracellular region] (R-HSA-8849629) proKLK5 [extracellular region] (R-HSA-8849836) KLK5 propeptide [extracellular region] (R-HSA-8849839) KLK5 [cytosol] (R-HSA-8934778)	0.527	2
UniProt:Q9ULZ2 STAP1			0.527	2
UniProt:P42773 CDKN2C	1	CDKN2C [cytosol] (R-HSA-182572)	0.527	4
IntAct:EBI-11746380 CDK6			0.488	2

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