Reactome | Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation

Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation

Stable Identifier

R-HSA-113638

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - E2F mediated regulation of DNA replication (Homo sapiens)
        
        E2F-enabled inhibition of pre-replication complex formation (Homo sapiens)
        
        Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation (Homo sapiens)

General

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Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation

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This event is inferred from the fission yeast. Cyclin B activity is thought to inhibit pre-RC formation by first associating with ORC during DNA replication.

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