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RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites
Stable Identifier
R-HSA-113442
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase III Transcription (Homo sapiens)
RNA Polymerase III Abortive And Retractive Initiation (Homo sapiens)
RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites (Homo sapiens)
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Productive transcription is accompanied by retractive RNase activity at U-tract pause sites and at the terminator. The principal cleavage products are dinucleotides, and they are produced in large stoichiometric excess over complete transcripts, despite the rapid overall rate of productive RNA chain elongation. This event is inferred from an event in Saccharomyces cerevisiae.
Participants
Input
elongating pre-RNA Pol III transcript plus 1 nucleotide [nucleoplasm]
Elongating RNA Polymerase III Transcription Complex [nucleoplasm]
(Homo sapiens)
Output
Elongating RNA Polymerase III Transcription Complex [nucleoplasm]
(Homo sapiens)
NDP [nucleoplasm]
paused pre-RNA Pol III transcript [nucleoplasm]
Participates
as an event of
RNA Polymerase III Abortive And Retractive Initiation (Homo sapiens)
Event Information
Go Biological Process
transcription by RNA polymerase III (0006383)
Inferred From
RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites (Saccharomyces cerevisiae)
Authored
Geiduschek, EP (2004-03-29)
Created
Gillespie, ME (2004-05-14)
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