MAPK1 (ERK2) activation

Stable Identifier
R-HSA-112411
Type
Pathway
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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MAPK1 (ERK2) activation
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Mitogen-activated protein kinase kinase MAP2K2 (also known as MEK2) is a dual threonine and tyrosine recognition kinase that phosphorylates and activates MAPK1 (ERK2) (Ohren et al. 2004; Roskoski 2012).
Literature References
PubMed ID Title Journal Year
22177953 MEK1/2 dual-specificity protein kinases: structure and regulation

Roskoski, R Jr

Biochem. Biophys. Res. Commun. 2012
8131746 Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues

Zheng, CF, Guan, KL

EMBO J 1994
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Event Information
Go Biological Process
ERK1 and ERK2 cascade (0070371)
Orthologous Events
MAPK1 (ERK2) activation (Bos taurus)
MAPK1 (ERK2) activation (Caenorhabditis elegans)
MAPK1 (ERK2) activation (Canis familiaris)
MAPK1 (ERK2) activation (Danio rerio)
MAPK1 (ERK2) activation (Dictyostelium discoideum)
MAPK1 (ERK2) activation (Drosophila melanogaster)
MAPK1 (ERK2) activation (Mus musculus)
MAPK1 (ERK2) activation (Rattus norvegicus)
MAPK1 (ERK2) activation (Saccharomyces cerevisiae)
MAPK1 (ERK2) activation (Schizosaccharomyces pombe)
MAPK1 (ERK2) activation (Sus scrofa)
Cross References
BioModels Database
Authored
Charalambous, M  (2005-02-04)
Reviewed
Greene, LA  (2007-11-08)
Created
Charalambous, M  (2004-04-29)
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