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Electric Transmission Across Gap Junctions
Stable Identifier
R-HSA-112303
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Neuronal System (Homo sapiens)
Transmission across Electrical Synapses (Homo sapiens)
Electric Transmission Across Gap Junctions (Homo sapiens)
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Electrical synapses are found in all nervous systems, including the human brain. The membranes of the two communicating neurons come extremely close at the synapse and are actually linked together by an intercellular specialization called a gap junction. Gap junctions contain precisely aligned, paired channels in the membrane of the pre- and postsynaptic neurons, such that each channel pair forms a pore. Electrical synapses thus work by allowing ionic current to flow passively through the gap junction pores from one neuron to another. Because passive current flow across the gap junction is virtually instantaneous, communication can occur without the delay that is characteristic of chemical synapses.
Participants
Events
Connexin 36 mediated neuronal gap junction communication
(Homo sapiens)
Connexin 45/Connexin 36 mediated neuronal gap junction communication
(Homo sapiens)
Connexin 62 mediated neuronal gap junction communication
(Homo sapiens)
Pannexin 1/Pannexin2 mediated neuronal gap junction communication
(Homo sapiens)
Participates
as an event of
Transmission across Electrical Synapses (Homo sapiens)
Orthologous Events
Electric Transmission Across Gap Junctions (Bos taurus)
Electric Transmission Across Gap Junctions (Canis familiaris)
Electric Transmission Across Gap Junctions (Danio rerio)
Electric Transmission Across Gap Junctions (Gallus gallus)
Electric Transmission Across Gap Junctions (Mus musculus)
Electric Transmission Across Gap Junctions (Rattus norvegicus)
Electric Transmission Across Gap Junctions (Sus scrofa)
Electric Transmission Across Gap Junctions (Xenopus tropicalis)
Authored
Joshi-Tope, G (2004-04-22)
Reviewed
Rush, MG (2008-01-11)
Created
Joshi-Tope, G (2004-04-22)
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