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SH2B2 [cytosol]
Stable Identifier
R-HSA-112195
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SH2B adapter protein 2, APS, SH2 and PH domain-containing adapter protein APS
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
SH2B proteins bind JAK2 (Homo sapiens)
SH2B family [cytosol] (Homo sapiens)
SH2B2 [cytosol] (Homo sapiens)
SH2B family:p-Y813-JAK2 [cytosol] (Homo sapiens)
SH2B family [cytosol] (Homo sapiens)
SH2B2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by SCF-KIT (Homo sapiens)
Regulation of KIT signaling (Homo sapiens)
Interaction of APS and p-KIT (Homo sapiens)
APS dimer [cytosol] (Homo sapiens)
SH2B2 [cytosol] (Homo sapiens)
APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Homo sapiens)
APS dimer [cytosol] (Homo sapiens)
SH2B2 [cytosol] (Homo sapiens)
Phosphorylation of APS (Homo sapiens)
APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Homo sapiens)
APS dimer [cytosol] (Homo sapiens)
SH2B2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14492 SH2B2
Gene Names
SH2B2, APS
Chain
chain:1-632
Reference Genes
BioGPS Gene:10603 SH2B2
COSMIC (genes):SH2B2 SH2B2
CTD Gene:10603 SH2B2
dbSNP Gene:10603 SH2B2
ENSEMBL:ENSG00000160999 SH2B2
HGNC:17381 SH2B2
KEGG Gene (Homo sapiens):10603 SH2B2
Monarch:10603 SH2B2
NCBI Gene:10603 SH2B2
OMIM:605300 SH2B2
UCSC:O14492 SH2B2
Reference Transcript
RefSeq:XM_005276977.4 SH2B2
RefSeq:XM_005276979.3 SH2B2
RefSeq:NM_020979.4 SH2B2
Participant Of
hasMember
SH2B family [cytosol]
hasComponent
APS dimer [cytosol]
Other forms of this molecule
p-Y629-SH2B2 [cytosol]
Inferred To
Ghost homologue of SH2B2 [cytosol] (Canis familiaris)
SH2B2 [cytosol] (Bos taurus)
SH2B2 [cytosol] (Sus scrofa)
Sh2b2 [cytosol] (Mus musculus)
Sh2b2 [cytosol] (Rattus norvegicus)
sh2b2 [cytosol] (Danio rerio)
sh2b2 [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_066189.3
,
XP_005277036.1
,
XP_005277034.1
OpenTargets
ENSG00000160999
GeneCards
O14492
PRO
O14492
PDB
1Q2H
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P22681 CBL
39
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL del366-409 [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
CBL G375fs*16 [cytosol]
(R-HSA-9706211)
CBL R420* [cytosol]
(R-HSA-9706208)
CBL H398D [cytosol]
(R-HSA-9706631)
CBL Y371C [cytosol]
(R-HSA-9706694)
CBL G375S [cytosol]
(R-HSA-9706214)
CBL Y371D [cytosol]
(R-HSA-9706687)
CBL Y371S [cytosol]
(R-HSA-9706674)
CBL P417S [cytosol]
(R-HSA-9706642)
CBL H398N [cytosol]
(R-HSA-9706641)
CBL R420P [cytosol]
(R-HSA-9706193)
CBL Y371N [cytosol]
(R-HSA-9706679)
CBL R499Q [cytosol]
(R-HSA-9706677)
CBL R420L [cytosol]
(R-HSA-9706197)
CBL P417H [cytosol]
(R-HSA-9706644)
p-Y371-CBL [plasma membrane]
(R-HSA-182923)
p-Y-CBL [cytosol]
(R-HSA-8875457)
p-Y371-CBL [cytosol]
(R-HSA-182940)
PolyUb,p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-8848826)
p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-912656)
CBL [cytosol]
(R-HSA-112199)
0.656
7
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