Reactome | SH2B2 [cytosol]

SH2B2 [cytosol]

Stable Identifier

R-HSA-112195

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SH2B adapter protein 2, APS, SH2 and PH domain-containing adapter protein APS

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O14492 SH2B2

Gene Names

SH2B2, APS

Chain

chain:1-632

Reference Genes

BioGPS Gene:10603 SH2B2

COSMIC (genes):SH2B2 SH2B2

CTD Gene:10603 SH2B2

dbSNP Gene:10603 SH2B2

ENSEMBL:ENSG00000160999 SH2B2

HGNC:17381 SH2B2

KEGG Gene (Homo sapiens):10603 SH2B2

Monarch:10603 SH2B2

NCBI Gene:10603 SH2B2

OMIM:605300 SH2B2

UCSC:O14492 SH2B2

Reference Transcript

Participant Of

hasMember

SH2B family [cytosol]

hasComponent

APS dimer [cytosol]

Other forms of this molecule

p-Y629-SH2B2 [cytosol]

Inferred To

Ghost homologue of SH2B2 [cytosol] (Canis familiaris)

SH2B2 [cytosol] (Bos taurus)

SH2B2 [cytosol] (Sus scrofa)

Sh2b2 [cytosol] (Mus musculus)

Sh2b2 [cytosol] (Rattus norvegicus)

sh2b2 [cytosol] (Danio rerio)

sh2b2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_066189.3, XP_005277036.1, XP_005277034.1

OpenTargets

ENSG00000160999

GeneCards

O14492

PRO

O14492

PDB

1Q2H

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P22681 CBL	39	CBL R420Q [cytosol] (R-HSA-9706186) CBL R420G [cytosol] (R-HSA-9706203) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL del366-409 [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637) CBL G375fs16 [cytosol] (R-HSA-9706211) CBL R420 [cytosol] (R-HSA-9706208) CBL H398D [cytosol] (R-HSA-9706631) CBL Y371C [cytosol] (R-HSA-9706694) CBL G375S [cytosol] (R-HSA-9706214) CBL Y371D [cytosol] (R-HSA-9706687) CBL Y371S [cytosol] (R-HSA-9706674) CBL P417S [cytosol] (R-HSA-9706642) CBL H398N [cytosol] (R-HSA-9706641) CBL R420P [cytosol] (R-HSA-9706193) CBL Y371N [cytosol] (R-HSA-9706679) CBL R499Q [cytosol] (R-HSA-9706677) CBL R420L [cytosol] (R-HSA-9706197) CBL P417H [cytosol] (R-HSA-9706644) p-Y371-CBL [plasma membrane] (R-HSA-182923) p-Y-CBL [cytosol] (R-HSA-8875457) p-Y371-CBL [cytosol] (R-HSA-182940) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) CBL [cytosol] (R-HSA-112199)	0.656	7

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