Reactome | p-Y629-SH2B2 [cytosol]

p-Y629-SH2B2 [cytosol]

Stable Identifier

R-HSA-112184

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-APS (Y629), SH2 and PH domain-containing adapter protein APS

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by SCF-KIT (Homo sapiens)
    - Regulation of KIT signaling (Homo sapiens)
      - Phosphorylation of APS (Homo sapiens)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Homo sapiens)
        
        p-APS dimer [cytosol] (Homo sapiens)
        
        p-Y629-SH2B2 [cytosol] (Homo sapiens)
      - Recruitment of CBL to KIT (Homo sapiens)
        
        CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Homo sapiens)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Homo sapiens)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Homo sapiens)
        
        p-APS dimer [cytosol] (Homo sapiens)
        
        p-Y629-SH2B2 [cytosol] (Homo sapiens)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Homo sapiens)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Homo sapiens)
        
        p-APS dimer [cytosol] (Homo sapiens)
        
        p-Y629-SH2B2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O14492 SH2B2

Gene Names

SH2B2, APS

Chain

chain:1-632

Reference Genes

BioGPS Gene:10603 O144922

COSMIC (genes):SH2B2 SH2B2

CTD Gene:10603 O144922

dbSNP Gene:10603 O144922

ENSEMBL:ENSG00000160999 SH2B2

HGNC:17381 O144922

Monarch:10603 O144922

NCBI Gene:10603 O144922

OMIM:605300 O144922

UCSC:O14492 O144922

Reference Transcript

Participates

as a component of

p-APS dimer [cytosol] (Homo sapiens)

Other forms of this molecule

SH2B2 [cytosol]

Inferred To

phospho-SH2B2 [cytosol] (Bos taurus)

phospho-SH2B2 [cytosol] (Canis familiaris)

phospho-SH2B2 [cytosol] (Sus scrofa)

phospho-Lnk [cytosol] (Drosophila melanogaster)

phospho-sh2b2 [cytosol] (Xenopus tropicalis)

phospho-Sh2b2 [cytosol] (Mus musculus)

phospho-Sh2b2 [cytosol] (Rattus norvegicus)

Ghost homologue of p-Y629-SH2B2 [cytosol] (Danio rerio)

Ghost homologue of p-Y629-SH2B2 [cytosol] (Gallus gallus)

Modified Residues

Name

O4'-phospho-L-tyrosine at 629

Coordinate

629

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

ENSEMBL

ENST00000536178, ENSP00000401883, ENST00000444095, ENSP00000440273, ENSG00000160999

OpenTargets

ENSG00000160999

GeneCards

SH2B2

HPA

ENSG00000160999-SH2B2

PRO

O14492

Pharos - Targets

O14492

PDB

1Q2H

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL [cytosol] (R-HSA-112199) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826)	0.656	7

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