Oxidative demethylation of 1-meA damaged DNA by ALKBH2

Stable Identifier
R-HSA-112118
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Oxidative demethylation of 1-meA damaged DNA by ALKBH2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
ALKBH2 catalyzes the removal of the methyl group from 1-methyladenine (1-meA) in a reaction that depends on oxygen, alpha-ketoglutarate and Fe2+. ALKBH2 thus directly reverses alkylation damage of DNA in the form of 1-meA, releasing formaldehyde. ALKBH2 is ~4-fold more active on dsDNA containing 1-methyladenine than 3-methylcytosine (Duncan et al. 2002).
Literature References
PubMed ID Title Journal Year
12486230 Reversal of DNA alkylation damage by two human dioxygenases.

Lindahl, T, Duncan, T, Bates, PA, Sedgwick, B, Trewick, SC, Koivisto, P

Proc Natl Acad Sci U S A 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

oxidative DNA demethylase activity of ALKBH2:Fe2+:1-meA-dsDNA [nucleoplasm]

Physical Entity
ALKBH2:Fe2+:1-meA-dsDNA [nucleoplasm] (Homo sapiens)
Activity
oxidative DNA demethylase activity (GO:0035516)
Authored
Pegg, AE  (2004-02-04)
Reviewed
Joshi-Tope, G  (2004-02-04)
Gillespie, ME  (2015-02-06)
Created
Joshi-Tope, G  (2004-04-09)
Cite Us!