Reactome | Cam-PDE 1 activation

Cam-PDE 1 activation

Stable Identifier

R-HSA-111957

Type

Pathway

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        Cam-PDE 1 activation (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        Cam-PDE 1 activation (Homo sapiens)

General

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Human Ca2+/calmodulin-dependent phosphodiesterase PDE1 is activated by the binding of calmodulin in the presence of Ca(2+). PDE1 has three subtypes PDE1A, PDE1B and PDE1C and their role is to hydrolyze both cGMP and cAMP. Their role is to antagonize the increased concentration of the intracellular second messengers determined by the synthetic activity of the adenylate cyclase enzymes thus governing intracellular cAMP dynamics in response to changes in the cytosolic Ca2+ concentration. PDE1 are mainly cytosolic but different isoforms are expressed in different tissues.

Literature References

PubMed ID	Title	Journal	Year
16786160	Regulation of calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1): review Sharma, RK, Das, SB, Lakshmikuttyamma, A, Selvakumar, P, Shrivastav, A	Int J Mol Med	2006
10442095	Calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1) Kakkar, R, Raju, RV, Sharma, RK	Cell Mol Life Sci	1999