Reactome | Calmodulin activates Cam-PDE 1

Calmodulin activates Cam-PDE 1

Stable Identifier

R-HSA-111956

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        Cam-PDE 1 activation (Homo sapiens)
        
        Calmodulin activates Cam-PDE 1 (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        Cam-PDE 1 activation (Homo sapiens)
        
        Calmodulin activates Cam-PDE 1 (Homo sapiens)

General

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Increased Ca2+ levels, acting via calmodulin, can activate PDE which can then act upon cAMP.

Literature References

PubMed ID	Title	Journal	Year
15272012	Sustained entry of Ca2+ is required to activate Ca2+-calmodulin-dependent phosphodiesterase 1A Ciruela, A, Goraya, TA, Masada, N, Cooper, DM	J Biol Chem	2004
18335582	Kinetic properties of Ca2+/calmodulin-dependent phosphodiesterase isoforms dictate intracellular cAMP dynamics in response to elevation of cytosolic Ca2+ Ciruela, A, Goraya, TA, Masada, N, Willoughby, D, Cooper, DM, Clynes, MA	Cell Signal	2008