Reactome | cAMP hydrolysis by Cam-PDE 1

cAMP hydrolysis by Cam-PDE 1

Stable Identifier

R-HSA-111955

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        Cam-PDE 1 activation (Homo sapiens)
        
        cAMP hydrolysis by Cam-PDE 1 (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        Cam-PDE 1 activation (Homo sapiens)
        
        cAMP hydrolysis by Cam-PDE 1 (Homo sapiens)

General

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Phosphodiesterases (PDEs) hydrolyze cAMP and cGMP, inactivating these second messengers.

Literature References

PubMed ID	Title	Journal	Year
17726023	Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes Vandeput, F, Wolda, SL, Krall, J, Hambleton, R, Uher, L, McCaw, KN, Radwanski, PB, Florio, V, Movsesian, MA	J Biol Chem	2007