cAMP hydrolysis by Cam-PDE 1

Stable Identifier
R-HSA-111955
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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cAMP hydrolysis by Cam-PDE 1
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Phosphodiesterases (PDEs) hydrolyze cAMP and cGMP, inactivating these second messengers.

Literature References
PubMed ID Title Journal Year
17726023 Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes

Wolda, SL, Krall, J, Uher, L, Radwanski, PB, Vandeput, F, Hambleton, R, Movsesian, MA, Florio, V, McCaw, KN

J Biol Chem 2007
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Catalyst Activity

calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity of activated PDE1 dimers [cytosol]

Physical Entity
activated PDE1 dimers [cytosol] (Homo sapiens)
Activity
calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity (GO:0004117)
Orthologous Events
cAMP hydrolysis by Cam-PDE 1 (Bos taurus)
cAMP hydrolysis by Cam-PDE 1 (Caenorhabditis elegans)
cAMP hydrolysis by Cam-PDE 1 (Canis familiaris)
cAMP hydrolysis by Cam-PDE 1 (Danio rerio)
cAMP hydrolysis by Cam-PDE 1 (Dictyostelium discoideum)
cAMP hydrolysis by Cam-PDE 1 (Drosophila melanogaster)
cAMP hydrolysis by Cam-PDE 1 (Gallus gallus)
cAMP hydrolysis by Cam-PDE 1 (Mus musculus)
cAMP hydrolysis by Cam-PDE 1 (Plasmodium falciparum)
cAMP hydrolysis by Cam-PDE 1 (Rattus norvegicus)
cAMP hydrolysis by Cam-PDE 1 (Sus scrofa)
cAMP hydrolysis by Cam-PDE 1 (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2004-03-31)
Le Novere, N  (2004-03-31)
Reviewed
Castagnoli, L  (2008-11-06)
Created
Schmidt, EE  (2004-03-26)
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