Reactome | cAMP hydrolysis by Cam-PDE 1

cAMP hydrolysis by Cam-PDE 1

Stable Identifier

R-HSA-111955

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        Cam-PDE 1 activation (Homo sapiens)
        
        cAMP hydrolysis by Cam-PDE 1 (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        Cam-PDE 1 activation (Homo sapiens)
        
        cAMP hydrolysis by Cam-PDE 1 (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phosphodiesterases (PDEs) hydrolyze cAMP and cGMP, inactivating these second messengers.

Literature References

PubMed ID	Title	Journal	Year
17726023	Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes Wolda, SL, Krall, J, Uher, L, Radwanski, PB, Vandeput, F, Hambleton, R, Movsesian, MA, Florio, V, McCaw, KN	J Biol Chem	2007