Reactome | PKA-mediated phosphorylation of CREB

PKA-mediated phosphorylation of CREB

Stable Identifier

R-HSA-111931

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane, nucleoplasm, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        PKA-mediated phosphorylation of CREB (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        PKA-mediated phosphorylation of CREB (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this pathway in the Pathway Browser

Cyclic adenosine 3',5'-monophosphate (cAMP) induces gene transcription through activation of cAMP-dependent protein kinase (PKA), and subsequent phosphorylation of the transcription factor cAMP response element-binding protein, CREB, at serine-133.

Literature References

PubMed ID	Title	Journal	Year
16125054	The cAMP signalling pathway activates CREB through PKA, p38 and MSK1 in NIH 3T3 cells Moens, U, Delghandi, MP, Johannessen, M	Cell Signal	2005
15337521	What turns CREB on? Moens, U, Delghandi, MP, Johannessen, M	Cell Signal	2004