Reactome | Opioid Signalling

Opioid Signalling

Stable Identifier

R-HSA-111885

DOI

10.3180/REACT_15295.1

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Opioids are chemical substances similar to opiates, the active substances found in opium (morphine, codeine etc.). Opioid action is mediated by the receptors for endogenous opioids; peptides such as the enkephalins, the endorphins or the dynorphins. Opioids possess powerful analgesic and sedative effects, and are widely used as pain-killers. Their main side-effect is the rapid establishment of a strong addiction. Opioids receptors are G-protein coupled receptors (GPCR). There are four classes of receptors: mu (MOR), kappa (KOR) and delta (DOR), and the nociceptin receptor (NOP).

Literature References

PubMed ID	Title	Journal	Year
16612131	Signal transduction induced by opioids in immune cells: a review Gabrilovac, J, Balog, T, Martin-Kleiner, I	Neuroimmunomodulation	2006
9218123	G proteins and opioid receptor-mediated signalling Pasternak, GW, Standifer, KM	Cell Signal	1997
9422713	The many faces of G protein signaling Hamm, HE	J Biol Chem	1998