Reactome | 2xHC-GLRX [cytosol]

2xHC-GLRX [cytosol]

Stable Identifier

R-HSA-111740

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

glutaredoxin (thioltransferase), oxidized, Glutaredoxin, Thioltransferase, TTase

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P35754 GLRX

Gene Names

GLRX, GRX

Chain

initiator methionine:1, chain:2-106

Reference Genes

BioGPS Gene:2745 GLRX

COSMIC (genes):GLRX GLRX

CTD Gene:2745 GLRX

dbSNP Gene:2745 GLRX

ENSEMBL:ENSG00000173221 GLRX

HGNC:4330 GLRX

KEGG Gene (Homo sapiens):2745 GLRX

Monarch:2745 GLRX

NCBI Gene:2745 GLRX

OMIM:600443 GLRX

UCSC:P35754 GLRX

Reference Transcript

Other Identifiers

11718048_a_at

11718049_s_at

11747441_a_at

206662_at

209276_s_at

2745

2867827

2867845

2867846

2867847

2867848

2867851

2867854

34311_at

8113214

A_23_P69908

GE54618

GO:0003674

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0006091

GO:0006464

GO:0006810

GO:0008150

GO:0009055

GO:0015035

GO:0015038

GO:0015949

GO:0016491

GO:0016740

GO:0022900

GO:0034641

GO:0043226

GO:0044281

GO:0045838

GO:0047485

GO:0055085

GO:0070062

GO:0080058

GO:0097573

GO:2000651

HMNXSV003055864

ILMN_1737308

PH_hs_0028834

X76648_at

g4504024_3p_at

g5442445_3p_a_at

Participates

as an output of

as an input of

glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Homo sapiens)

Other forms of this molecule

GLRX [cytosol]

Inferred To

Glrx [cytosol] (Mus musculus)

Glrx [cytosol] (Rattus norvegicus)

2xHC-GLRX [cytosol] (Bos taurus)

2xHC-GLRX [cytosol] (Plasmodium falciparum)

glrx [cytosol] (Danio rerio)

glrx [cytosol] (Xenopus tropicalis)

GLRX [cytosol] (Canis familiaris)

GLRX [cytosol] (Gallus gallus)

GLRX [cytosol] (Sus scrofa)

glrx-10 [cytosol] (Caenorhabditis elegans)

Modified Residues

Name

Intra-chain Crosslink via L-cystine (cross-link) at 23 and 26

Coordinate

PsiMod Name

L-cystine (cross-link)

PsiMod Definition

A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.

Cross References

RefSeq

NP_002055.1, NP_001230588.1, NP_001112362.1, NP_001230587.1

OpenTargets

ENSG00000173221

HPA

ENSG00000173221-GLRX

GeneCards

P35754

Ensembl

ENSP00000422708, ENST00000512469, ENST00000237858, ENST00000508780, ENST00000379979, ENSP00000424636, ENST00000505427, ENSG00000173221, ENSP00000427353, ENSP00000369314, ENSP00000237858

PRO

P35754

Pharos - Targets

P35754

GlyGen

P35754

PDB

1B4Q, 4RQR, 1JHB

HMDB Protein

HMDBP01692

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTD1-PRO_0000449623 REP			0.558	2
glutathione [ChEBI:16856]	5	GSH [endoplasmic reticulum membrane] (R-ALL-2239524) GSH [endoplasmic reticulum lumen] (R-ALL-158543) GSH [periplasmic space] (R-ALL-1500783) GSH [mitochondrial matrix] (R-ALL-1655887) GSH [extracellular region] (R-ALL-1247892)	0.558	2
UniProt:Q9BVG3 TRIM62	1	TRIM62 [cytosol] (R-HSA-5624340)	0.556	5

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