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2xHC-GLRX [cytosol]
Stable Identifier
R-HSA-111740
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
glutaredoxin (thioltransferase), oxidized, Glutaredoxin, Thioltransferase, TTase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of nucleotides (Homo sapiens)
Interconversion of nucleotide di- and triphosphates (Homo sapiens)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Homo sapiens)
2xHC-GLRX [cytosol] (Homo sapiens)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Homo sapiens)
2xHC-GLRX [cytosol] (Homo sapiens)
glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Homo sapiens)
2xHC-GLRX [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35754 GLRX
Gene Names
GLRX, GRX
Chain
initiator methionine:, chain:2-106
Reference Genes
BioGPS Gene:2745 GLRX
COSMIC (genes):GLRX GLRX
CTD Gene:2745 GLRX
dbSNP Gene:2745 GLRX
ENSEMBL:ENSG00000173221 GLRX
HGNC:4330 GLRX
KEGG:hsa:2745 GLRX
Monarch:2745 GLRX
NCBI Gene:2745 GLRX
OMIM:600443 GLRX
UCSC:P35754 GLRX
Reference Transcript
RefSeq:NM_002064.3 GLRX
RefSeq:NM_001243659.2 GLRX
RefSeq:NM_001243658.2 GLRX
RefSeq:NM_001118890.2 GLRX
Other Identifiers
11718048_a_at
11718049_s_at
11747441_a_at
206662_PM_at
206662_at
209276_PM_s_at
209276_s_at
2745
2867827
2867833
2867837
2867845
2867846
2867847
2867848
2867851
2867852
2867853
2867854
34311_at
8113214
A_23_P69908
GE54618
GO:0003824
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0015038
GO:0015949
GO:0016491
GO:0017080
GO:0043226
GO:0045838
GO:0055086
GO:0070062
GO:0098772
HMNXSV003055864
ILMN_1737308
PH_hs_0028834
PH_hs_0038841
X76648_at
g4504024_3p_at
g5442445_3p_a_at
Participates
as an output of
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Homo sapiens)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Homo sapiens)
as an input of
glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Homo sapiens)
Other forms of this molecule
GLRX [cytosol]
Inferred To
Glrx [cytosol]
(Mus musculus)
Glrx [cytosol]
(Rattus norvegicus)
2xHC-GLRX [cytosol]
(Bos taurus)
2xHC-GLRX [cytosol]
(Plasmodium falciparum)
glrx [cytosol]
(Danio rerio)
glrx [cytosol]
(Xenopus tropicalis)
GLRX [cytosol]
(Canis familiaris)
GLRX [cytosol]
(Gallus gallus)
GLRX [cytosol]
(Sus scrofa)
glrx-10 [cytosol]
(Caenorhabditis elegans)
Modified Residues
Name
Intra-chain Crosslink via L-cystine (cross-link) at 23 and 26
Coordinate
23
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Cross References
RefSeq
NP_002055.1
,
NP_001230588.1
,
NP_001230587.1
,
NP_001112362.1
ENSEMBL
ENST00000508780
,
ENST00000505427
,
ENSP00000237858
,
ENST00000379979
,
ENSP00000427353
,
ENST00000237858
,
ENSP00000422708
,
ENSG00000173221
,
ENSP00000424636
,
ENSP00000369314
,
ENST00000512469
OpenTargets
ENSG00000173221
GeneCards
GLRX
HPA
ENSG00000173221-GLRX
PRO
P35754
Pharos - Targets
P35754
GlyGen
P35754
HMDB Protein
HMDBP01692
PDB
1B4Q
,
4RQR
,
1JHB
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0DTD1-PRO_0000449623 REP
0.558
2
glutathione [ChEBI:16856]
5
GSH [endoplasmic reticulum membrane]
(R-ALL-2239524)
GSH [endoplasmic reticulum lumen]
(R-ALL-158543)
GSH [periplasmic space]
(R-ALL-1500783)
GSH [mitochondrial matrix]
(R-ALL-1655887)
GSH [extracellular region]
(R-ALL-1247892)
0.558
2
UniProt:Q9BVG3 TRIM62
1
TRIM62 [cytosol]
(R-HSA-5624340)
0.556
5
UniProt:P57076 CF298
0.527
2
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