In response to apoptotic signals, mitochondrial proteins are released into the cytosol and activate both caspase-dependent and -independent cell death pathways. Cytochrome c induces apoptosome formation, AIF and endonuclease G function in caspase independent apoptotic nuclear DNA damage. Smac/DIABLO and HtrA2/OMI promote both caspase activation and caspase-independent cytotoxicity (Saelens et al., 2004).
Salvesen, GS, Duckett, CS
Saelens, X, Festjens, N, Vande Walle, L, van Gurp, M, van Loo, G, Vandenabeele, P
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