Reactome | Apoptotic factor-mediated response

Apoptotic factor-mediated response

Stable Identifier

R-HSA-111471

Type

Pathway

Species

Homo sapiens

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In response to apoptotic signals, mitochondrial proteins are released into the cytosol and activate both caspase-dependent and -independent cell death pathways. Cytochrome c induces apoptosome formation, AIF and endonuclease G function in caspase independent apoptotic nuclear DNA damage. Smac/DIABLO and HtrA2/OMI promote both caspase activation and caspase-independent cytotoxicity (Saelens et al., 2004).

Literature References

PubMed ID	Title	Journal	Year
12042762	IAP proteins: blocking the road to death's door Salvesen, GS, Duckett, CS	Nat Rev Mol Cell Biol	2002
15077149	Toxic proteins released from mitochondria in cell death Saelens, X, Festjens, N, Vande Walle, L, van Gurp, M, van Loo, G, Vandenabeele, P	Oncogene	2004