Activation and oligomerization of BAK protein

Stable Identifier
R-HSA-111452
Type
Pathway
Species
Homo sapiens
Compartment
mitochondrial outer membrane
ReviewStatus
5/5
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Activation and oligomerization of BAK protein
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tBID binds to its mitochondrial partner BAK to release cytochrome c. Activated tBID results in an allosteric activation of BAK. This may induce its intramembranous oligomerization into a pore for cytochrome c efflux.

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Event Information
Go Biological Process
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (1901030)
Orthologous Events
Activation and oligomerization of BAK protein (Bos taurus)
Activation and oligomerization of BAK protein (Canis familiaris)
Activation and oligomerization of BAK protein (Gallus gallus)
Activation and oligomerization of BAK protein (Mus musculus)
Activation and oligomerization of BAK protein (Rattus norvegicus)
Activation and oligomerization of BAK protein (Sus scrofa)
Activation and oligomerization of BAK protein (Xenopus tropicalis)
Cross References
BioModels Database
Created
Hardwick, JM  (2004-08-09)
Tsujimoto, Y  (2004-08-09)
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