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Docking of Mature Histone mRNA complex:TAP at the NPC
Stable Identifier
R-HSA-111439
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
,
nuclear envelope
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Transport of Mature Transcript to Cytoplasm (Homo sapiens)
Transport of Mature mRNAs Derived from Intronless Transcripts (Homo sapiens)
Transport of the SLBP independent Mature mRNA (Homo sapiens)
Docking of Mature Histone mRNA complex:TAP at the NPC (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Histone mRNAs are exported by a mechanism that requires TAP, the key factor required for transport of polyadenylated mRNAs. How TAP is recruited to the histone mRNAs is not known, but it is clear that transport can occur in the absence of either the stemloop or of SLBP. The mature transcript docks at the NPC. In the course of transport, CBC is lost from the mRNA cap, and remain in the nucleous.
Participants
Input
ALYREF [nucleoplasm]
(Homo sapiens)
Mature intronless transcript derived Histone pre-mRNA:CBC complex [nucleoplasm]
(Homo sapiens)
NXF1 [nucleoplasm]
(Homo sapiens)
Output
Cap Binding Complex (CBC) [nucleoplasm]
(Homo sapiens)
Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref complex [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Transport of the SLBP independent Mature mRNA (Homo sapiens)
Event Information
Go Biological Process
mRNA export from nucleus (0006406)
This event is regulated
Requirements
Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]'
Orthologous Events
Docking of Mature Histone mRNA complex:TAP at the NPC (Bos taurus)
Docking of Mature Histone mRNA complex:TAP at the NPC (Canis familiaris)
Docking of Mature Histone mRNA complex:TAP at the NPC (Drosophila melanogaster)
Docking of Mature Histone mRNA complex:TAP at the NPC (Gallus gallus)
Docking of Mature Histone mRNA complex:TAP at the NPC (Mus musculus)
Docking of Mature Histone mRNA complex:TAP at the NPC (Rattus norvegicus)
Docking of Mature Histone mRNA complex:TAP at the NPC (Schizosaccharomyces pombe)
Docking of Mature Histone mRNA complex:TAP at the NPC (Sus scrofa)
Authored
Marzluff, WF (2003-08-22)
Created
Marzluff, WF (2003-08-22)
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