POU5F1 (OCT4), SOX2, NANOG, ZSCAN10, PRDM14, SMAD2, FOXP1-ES bind the POU5F1 (OCT4) promoter

Stable Identifier
Reaction [binding]
Homo sapiens
Formation of OCT4:SOX2:NANOG:ZSCAN10:PRDM14:SMAD2:FOXP1-ES Complex at OCT4 Promoter
Locations in the PathwayBrowser
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POU5F1 (OCT4), SOX2, and NANOG bind distinct sites in the promoter of the POU5F1 gene (Boyer et al. 2005, Chew et al. 2005, Rodda et al. 2005, Jin et al. 2007, Lister et al. 2009, Jung et al. 2010, Goke et al. 2011). The set of target genes of POU5F1, SOX2, and NANOG includes POU5F1, SOX2, and NANOG themselves, thus their expression is a component of an autoregulatory loop . Activin/Nodal signaling also regulates POU5F1 transcription via SMAD2 and SMAD3 (Brown et al. 2011). PRDM14 binds the POU5F1 promoter and regulates transcription (Chia et al. 2010).
Literature References
PubMed ID Title Journal Year
19829295 Human DNA methylomes at base resolution show widespread epigenomic differences

Thomson, JA, Nery, JR, Ye, Z, Pelizzola, M, Ruotti, V, Lister, R, Antosiewicz-Bourget, J, Tonti-Filippini, J, Edsall, L, Hawkins, RD, Lee, L, Ecker, JR, Dowen, RH, Hon, G, Ren, B, Ngo, QM, Stewart, R, Millar, AH

Nature 2009
16153702 Core transcriptional regulatory circuitry in human embryonic stem cells

Gifford, DK, Jaenisch, R, Lee, TI, Young, RA, Kumar, RM, Guenther, MG, Levine, SS, Boyer, LA, Jenner, RG, Cole, MF, Zucker, JP, Murray, HL, Johnstone, SE, Melton, DA

Cell 2005
17567999 Identification of an OCT4 and SRY regulatory module using integrated computational and experimental genomics approaches

O'Geen, H, Jin, VX, Farnham, PJ, Green, R, Iyengar, S

Genome Res. 2007
21924763 An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming

Wrana, JL, Mazzoni, EO, Gabut, M, Alvarez, M, Wang, X, Pan, Q, Blencowe, BJ, Zandstra, PW, Nedelec, S, Sung, HK, Woltjen, K, Samavarchi-Tehrani, P, Hughes, TR, Slobodeniuc, V, O'Hanlon, D, Talukder, S, Nagy, A, Wichterle, H

Cell 2011
20953172 A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity

Chan, YS, Lufkin, T, Jiang, J, Yang, L, Moreau, D, Clarke, ND, Lu, X, Orlov, YL, Soh, BS, Huss, M, Lau, MS, Lim, B, Feng, B, Kumar, P, Chia, NY, Ng, HH, Kraus, P, Bard, F, Li, P

Nature 2010
22215994 Combinatorial binding in human and mouse embryonic stem cells identifies conserved enhancers active in early embryonic development

O'Keeffe, S, Lehrach, H, Göke, J, Timmermann, B, Jung, M, Vingron, M, Adjaye, J, Chavez, L, Behrens, S

PLoS Comput. Biol. 2011
21630377 Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors

Dunn, NR, Lim, B, Cho, CH, Vallier, L, Pedersen, R, Hannan, N, Teo, A, Vardy, L, Brown, S, Trotter, M, Pauklin, S

Stem Cells 2011
20505756 A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells

Adjaye, J, Kahlem, P, Lehrach, H, Vilo, J, Peterson, H, Chavez, L, Jung, M

PLoS One 2010
15988017 Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells

Robson, P, Tam, WL, Ang, YS, Lim, B, Loh, YH, Ng, HH, Chen, X, Li, P, Zhang, W, Yeap, LS, Chew, JL

Mol Cell Biol 2005
17068183 Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Babaie, Y, Groth, D, Wruck, W, Greber, B, Lehrach, H, Brink, TC, Burdon, T, Herwig, R, Adjaye, J

Stem Cells 2007
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