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Activated JAK1, JAK2, TYK2 [cytosol]
Stable Identifier
R-HSA-1112596
Type
Set [CandidateSet]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-6 family signaling (Homo sapiens)
Interleukin-6 signaling (Homo sapiens)
IL6ST is tyrosine phosphorylated (Homo sapiens)
IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
JAK activation (Homo sapiens)
IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
PTPN11 binds CBL (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
PTPN11 binds p-Y759-IL6ST (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
PTPN11 is phosphorylated (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
Phosphorylated STATs are released (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
SOCS3 binds IL6ST (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
Serine phosphorylation of STATs (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine/serine phosphorylated STAT1/3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF-independent MAPK1/3 activation (Homo sapiens)
MAPK1 (ERK2) activation (Homo sapiens)
MAP2K2 binds MAPK1 (Homo sapiens)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
MAPK3 (ERK1) activation (Homo sapiens)
MAP2K1 binds MAPK3 (Homo sapiens)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
Participants
members
p-Y1034-JAK1 [cytosol]
(Homo sapiens)
p-Y1007-JAK2 [cytosol]
(Homo sapiens)
candidates
p-Y1054-TYK2 [cytosol]
(Homo sapiens)
Participates
as a component of
IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Inferred To
Activated JAK1, JAK2, TYK2 [cytosol]
(Bos taurus)
Activated JAK1, JAK2, TYK2 [cytosol]
(Canis familiaris)
Activated JAK1, JAK2, TYK2 [cytosol]
(Danio rerio)
Activated JAK1, JAK2, TYK2 [cytosol]
(Gallus gallus)
Activated JAK1, JAK2, TYK2 [cytosol]
(Mus musculus)
Activated JAK1, JAK2, TYK2 [cytosol]
(Rattus norvegicus)
Activated JAK1, JAK2, TYK2 [cytosol]
(Sus scrofa)
Activated JAK1, JAK2, TYK2 [cytosol]
(Xenopus tropicalis)
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