Tyrosine phosphorylated IL6ST binds STAT1,STAT3

Stable Identifier
R-HSA-1112565
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
STATs bind gp130 phosphotyrosines
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

STAT1 binds to IL6ST (gp130) via phosphotyrosine residues 905 and 915 within two YXPD recognition motifs. STAT3 can be recruited to these sites and to two additional sites around Y767 and Y814 that have less restricted sequence recognition requirements (YXXQ) (Gerhartz et al. 1996). After receptor binding, STATs are phosphorylated on a single tyrosine residue by JAKs (Hemmann et al. 1996).

Literature References
PubMed ID Title Journal Year
8662591 Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation

Gerhartz, C, Heesel, B, Sasse, J, Hemmann, U, Landgraf, C, Schneider-Mergener, J, Horn, F, Heinrich, PC, Graeve, L

J Biol Chem 1996
8662795 Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation

Hemmann, U, Gerhartz, C, Heesel, B, Sasse, J, Kurapkat, G, Grötzinger, J, Wollmer, A, Zhong, Z, Darnell JE, Jr, Graeve, L, Heinrich, PC, Horn, F

J Biol Chem 1996
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created