Reactome | Tyrosine phosphorylated IL6ST binds STAT1,STAT3

Tyrosine phosphorylated IL6ST binds STAT1,STAT3

Stable Identifier

R-HSA-1112565

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

Synonyms

STATs bind gp130 phosphotyrosines

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Tyrosine phosphorylated IL6ST binds STAT1,STAT3

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

STAT1 binds to IL6ST (gp130) via phosphotyrosine residues 905 and 915 within two YXPD recognition motifs. STAT3 can be recruited to these sites and to two additional sites around Y767 and Y814 that have less restricted sequence recognition requirements (YXXQ) (Gerhartz et al. 1996). After receptor binding, STATs are phosphorylated on a single tyrosine residue by JAKs (Hemmann et al. 1996).

Literature References

PubMed ID	Title	Journal	Year
8662795	Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation Heinrich, PC, Sasse, J, Horn, F, Darnell JE, Jr, Zhong, Z, Graeve, L, Hemmann, U, Wollmer, A, Kurapkat, G, Heesel, B, Grötzinger, J, Gerhartz, C	J Biol Chem	1996
8662591	Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation Heinrich, PC, Landgraf, C, Sasse, J, Horn, F, Schneider-Mergener, J, Graeve, L, Hemmann, U, Heesel, B, Gerhartz, C	J Biol Chem	1996