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Resolution of AP sites via the single-nucleotide replacement pathway
Stable Identifier
R-HSA-110381
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Resolution of Abasic Sites (AP sites) (Homo sapiens)
Resolution of AP sites via the single-nucleotide replacement pathway (Homo sapiens)
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The single nucleotide replacement pathway of base excision repair appears to facilitate the repair of most damaged bases. Following DNA glycosylase mediated cleavage of the damaged base, the endonuclease APEX1 is recruited to the site of damage where it cleaves the 5' side of the abasic (AP) deoxyribose residue. DNA polymerase beta (POLB) then cleaves the 3' side of the AP sugar phosphate, thus excising the AP residue. APEX1 is subsequently released, the XRCC1:LIG3 complex is recruited, and POLB mediates the synthesis of the replacement residue. Following LIG3 mediated ligation of the replaced residue, the XRCC1:LIG3 complex dissociates from DNA (Lindahl and Wood, 1999). An alternative BER pathway is employed when the structure of the terminal sugar phosphate is such that it cannot be cleaved by the AP lyase activity of POLB.
Literature References
PubMed ID
Title
Journal
Year
10583946
Quality control by DNA repair
Lindahl, T
,
Wood, RD
Science
1999
Participants
Events
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway
(Homo sapiens)
Recruitment of LIG3:XRCC1 complex to the site of repair by POLB
(Homo sapiens)
Resynthesis of excised residue by POLB
(Homo sapiens)
LIG3-mediated DNA ligation via the single-nucleotide replacement pathway
(Homo sapiens)
Dissociation of LIG3:XRCC1 complex from the BER site
(Homo sapiens)
Participates
as an event of
Resolution of Abasic Sites (AP sites) (Homo sapiens)
Event Information
Go Biological Process
base-excision repair, gap-filling (0006287)
Orthologous Events
Resolution of AP sites via the single-nucleotide replacement pathway (Bos taurus)
Resolution of AP sites via the single-nucleotide replacement pathway (Canis familiaris)
Resolution of AP sites via the single-nucleotide replacement pathway (Danio rerio)
Resolution of AP sites via the single-nucleotide replacement pathway (Dictyostelium discoideum)
Resolution of AP sites via the single-nucleotide replacement pathway (Mus musculus)
Resolution of AP sites via the single-nucleotide replacement pathway (Rattus norvegicus)
Resolution of AP sites via the single-nucleotide replacement pathway (Sus scrofa)
Resolution of AP sites via the single-nucleotide replacement pathway (Xenopus tropicalis)
Authored
Matthews, L (2004-02-09)
Reviewed
Borowiec, JA (2014-12-22)
Created
Matthews, L (2004-01-29)
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