PCNA-bound FEN1 acts as a flap endonuclease to cleave the displaced single strand DNA (flap) containing the oxidatively damaged AP (apurinic/apyrimidinic) dideoxyribose residue (5'ddRP) that could not be excised by POLB. Interaction between FEN1 and PCNA or FEN1 and APE1 facilitate cleavage of flap structures (Klungland and Lindahl 1997, Matsumoto et al. 1999, Dianov et al. 1999).
Klungland, A, Lindahl, T
Dianov, GL, Jensen, BR, Kenny, MK, Bohr, VA
Matsumoto, Y, Kim, K, Hurwitz, J, Gary, R, Levin, DS, Tomkinson, AE, Park, MS
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