Cleavage of hypoxanthine by MPG glycosylase

Stable Identifier
R-HSA-110251
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Cleavage of hypoxanthine by MPG glycosylase
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MPG, 3-methyladenine DNA glycosylase, cleaves the alkylated DNA base hypoxanthine (Saparbaev and Laval 1994).
Literature References
PubMed ID Title Journal Year
8016081 Excision of hypoxanthine from DNA containing dIMP residues by the Escherichia coli, yeast, rat, and human alkylpurine DNA glycosylases

Laval, J, Saparbaev, M

Proc. Natl. Acad. Sci. U.S.A. 1994
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Catalyst Activity

DNA N-glycosylase activity of MPG:Hyp-dsDNA [nucleoplasm]

Physical Entity
MPG:Hyp-dsDNA [nucleoplasm] (Homo sapiens)
Activity
DNA N-glycosylase activity (GO:0019104)
Orthologous Events
Cleavage of hypoxanthine by MPG glycosylase (Bos taurus)
Cleavage of hypoxanthine by MPG glycosylase (Canis familiaris)
Cleavage of hypoxanthine by MPG glycosylase (Danio rerio)
Cleavage of hypoxanthine by MPG glycosylase (Gallus gallus)
Cleavage of hypoxanthine by MPG glycosylase (Mus musculus)
Cleavage of hypoxanthine by MPG glycosylase (Plasmodium falciparum)
Cleavage of hypoxanthine by MPG glycosylase (Rattus norvegicus)
Cleavage of hypoxanthine by MPG glycosylase (Sus scrofa)
Cleavage of hypoxanthine by MPG glycosylase (Xenopus tropicalis)
Authored
Matthews, L  (2004-02-03)
Reviewed
Borowiec, JA  (2014-12-22)
Created
Matthews, L  (2004-01-29)
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