OGG1 acts as an N-glycosylase and a DNA beta-lyase to excise 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG), a one electron reduction product of guanine, from the DNA and to nickk the sugar-phosphate backbone 5' to the created apurinic/apyrimidinic (AP) site (Hu et al. 2005).
Dizdaroglu, M, Hogue, BA, Bohr, VA, de Souza-Pinto, NC, Jaruga, P, Haraguchi, K, Greenberg, MM, Hu, J
oxidized purine nucleobase lesion DNA N-glycosylase activity of OGG1:FapyG-dsDNA [nucleoplasm]
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