Excision of FapyG by OGG1 glycosylase

Stable Identifier
R-HSA-110244
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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OGG1 acts as an N-glycosylase and a DNA beta-lyase to excise 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG), a one electron reduction product of guanine, from the DNA and to nickk the sugar-phosphate backbone 5' to the created apurinic/apyrimidinic (AP) site (Hu et al. 2005).

Literature References
PubMed ID Title Journal Year
16221681 Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes

Hu, J, de Souza-Pinto, NC, Haraguchi, K, Hogue, BA, Jaruga, P, Greenberg, MM, Dizdaroglu, M, Bohr, VA

J. Biol. Chem. 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
oxidized purine nucleobase lesion DNA N-glycosylase activity of OGG1:FapyG-dsDNA [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created