Excision of FapyG by OGG1 glycosylase

Stable Identifier
R-HSA-110244
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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Excision of FapyG by OGG1 glycosylase
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OGG1 acts as an N-glycosylase and a DNA beta-lyase to excise 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG), a one electron reduction product of guanine, from the DNA and to nickk the sugar-phosphate backbone 5' to the created apurinic/apyrimidinic (AP) site (Hu et al. 2005).

Literature References
PubMed ID Title Journal Year
16221681 Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes

Hu, J, de Souza-Pinto, NC, Haraguchi, K, Hogue, BA, Jaruga, P, Greenberg, MM, Dizdaroglu, M, Bohr, VA

J. Biol. Chem. 2005
Participants
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Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
oxidized purine nucleobase lesion DNA N-glycosylase activity of OGG1:FapyG-dsDNA [nucleoplasm]
Physical Entity
OGG1:FapyG-dsDNA [nucleoplasm]
Activity
oxidized purine nucleobase lesion DNA N-glycosylase activity (0008534)
Orthologous Events
Excision of FapyG by OGG1 glycosylase (Bos taurus)
Excision of FapyG by OGG1 glycosylase (Canis familiaris)
Excision of FapyG by OGG1 glycosylase (Danio rerio)
Excision of FapyG by OGG1 glycosylase (Dictyostelium discoideum)
Excision of FapyG by OGG1 glycosylase (Drosophila melanogaster)
Excision of FapyG by OGG1 glycosylase (Gallus gallus)
Excision of FapyG by OGG1 glycosylase (Mus musculus)
Excision of FapyG by OGG1 glycosylase (Plasmodium falciparum)
Excision of FapyG by OGG1 glycosylase (Rattus norvegicus)
Excision of FapyG by OGG1 glycosylase (Saccharomyces cerevisiae)
Excision of FapyG by OGG1 glycosylase (Sus scrofa)
Excision of FapyG by OGG1 glycosylase (Xenopus tropicalis)
Authored
Matthews, L  (2004-02-03)
Reviewed
Borowiec, JA  (2014-12-22)
Vlahopoulos, S  (2019-10-02)
Boldogh, I  (2019-10-08)
Created
Matthews, L  (2004-01-29)