Reactome | Cleavage of uracil by SMUG1 glycosylase

Cleavage of uracil by SMUG1 glycosylase

Stable Identifier

R-HSA-110221

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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SMUG1 is a single-strand selective monofunctional uracil DNA glycosylase that cleaves uracil from the sugar phosphate backbone of DNA. SMUG1 has the highest preference for uracil in single strand DNA, followed by A:U and then G:U pairs in double strand DNA (Haushalter et al. 1999, Masaoka et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12718543	Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions Kurisu, S, Hasegawa, R, Matsuda, A, Karino, N, Ohyama, Y, Ide, H, Matsubara, M, Terato, H, Masaoka, A, Tanaka, T	Biochemistry	2003
10074426	Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors Haushalter, KA, Kirschner, MW, Todd Stukenberg, MW, Verdine, GL	Curr. Biol.	1999