SMUG1 is a single-strand selective monofunctional uracil DNA glycosylase that cleaves uracil from the sugar phosphate backbone of DNA. SMUG1 has the highest preference for uracil in single strand DNA, followed by A:U and then G:U pairs in double strand DNA (Haushalter et al. 1999, Masaoka et al. 2003).
Haushalter, KA, Kirschner, MW, Todd Stukenberg, MW, Verdine, GL
Kurisu, S, Hasegawa, R, Matsuda, A, Karino, N, Ohyama, Y, Ide, H, Matsubara, M, Terato, H, Masaoka, A, Tanaka, T
single-strand selective uracil DNA N-glycosylase activity of SMUG1:Ura-DNA [nucleoplasm]
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