Cleavage of uracil by SMUG1 glycosylase

Stable Identifier
R-HSA-110221
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SMUG1 is a single-strand selective monofunctional uracil DNA glycosylase that cleaves uracil from the sugar phosphate backbone of DNA. SMUG1 has the highest preference for uracil in single strand DNA, followed by A:U and then G:U pairs in double strand DNA (Haushalter et al. 1999, Masaoka et al. 2003).

Literature References
PubMed ID Title Journal Year
10074426 Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors

Haushalter, KA, Kirschner, MW, Todd Stukenberg, MW, Verdine, GL

Curr. Biol. 1999
12718543 Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions

Kurisu, S, Hasegawa, R, Matsuda, A, Karino, N, Ohyama, Y, Ide, H, Matsubara, M, Terato, H, Masaoka, A, Tanaka, T

Biochemistry 2003
Participants
Participates
Catalyst Activity

single-strand selective uracil DNA N-glycosylase activity of SMUG1:Ura-DNA [nucleoplasm]

Orthologous Events
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