Cleavage of uracil by SMUG1 glycosylase

Stable Identifier
R-HSA-110221
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SMUG1 is a single-strand selective monofunctional uracil DNA glycosylase that cleaves uracil from the sugar phosphate backbone of DNA. SMUG1 has the highest preference for uracil in single strand DNA, followed by A:U and then G:U pairs in double strand DNA (Haushalter et al. 1999, Masaoka et al. 2003).
Literature References
PubMed ID Title Journal Year
12718543 Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions

Kurisu, S, Hasegawa, R, Matsuda, A, Karino, N, Ohyama, Y, Ide, H, Matsubara, M, Terato, H, Masaoka, A, Tanaka, T

Biochemistry 2003
10074426 Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors

Haushalter, KA, Kirschner, MW, Todd Stukenberg, MW, Verdine, GL

Curr. Biol. 1999
Participants
Participates
Catalyst Activity

single-strand selective uracil DNA N-glycosylase activity of SMUG1:Ura-DNA [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
Cite Us!