TDG, a G/T mismatch-specific thymine DNA glycosylase, cleaves thymine, generated through 5-methylcytosine deamination and mispaired with guanine, from the DNA sugar-phosphate backbone, leaving an apurinic/apyrimidinic (AP) site (Neddermann and Jiricny 1993, Neddermann et al. 1996).
Jiricny, J, Neddermann, P
Jiricny, J, Lettieri, T, Schmid, D, Gallinari, P, Hsuan, JJ, Neddermann, P, Truong, O, Wiebauer, K
DNA N-glycosylase activity of TDG:(T:G)-dsDNA [nucleoplasm]
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