Reactome | Cleavage of thymine by TDG glycosylase

Cleavage of thymine by TDG glycosylase

Stable Identifier

R-HSA-110219

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

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TDG, a G/T mismatch-specific thymine DNA glycosylase, cleaves thymine, generated through 5-methylcytosine deamination and mispaired with guanine, from the DNA sugar-phosphate backbone, leaving an apurinic/apyrimidinic (AP) site (Neddermann and Jiricny 1993, Neddermann et al. 1996).

Literature References

PubMed ID	Title	Journal	Year
8407958	The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells Jiricny, J, Neddermann, P	J. Biol. Chem.	1993
8662714	Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase Jiricny, J, Lettieri, T, Schmid, D, Gallinari, P, Hsuan, JJ, Neddermann, P, Truong, O, Wiebauer, K	J. Biol. Chem.	1996