Reactome | Cleavage of uracil by TDG glycosylase

Cleavage of uracil by TDG glycosylase

Stable Identifier

R-HSA-110218

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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TDG is a G/T mismatch-specific thymine DNA glycosylase that cleaves uracil mispaired with guanine as a consequence of cytosine deamination, leaving an apurinic/apyrimidinic (AP) site in the DNA (Neddermann and Jiricny 1993, Hashimoto et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
8407958	The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells Neddermann, P, Jiricny, J	J. Biol. Chem.	1993
22962365	Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation Hashimoto, H, Hong, S, Bhagwat, AS, Zhang, X, Cheng, X	Nucleic Acids Res.	2012