Cleavage of uracil by TDG glycosylase

Stable Identifier
R-HSA-110218
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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TDG is a G/T mismatch-specific thymine DNA glycosylase that cleaves uracil mispaired with guanine as a consequence of cytosine deamination, leaving an apurinic/apyrimidinic (AP) site in the DNA (Neddermann and Jiricny 1993, Hashimoto et al. 2012).

Literature References
PubMed ID Title Journal Year
22962365 Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation

Hashimoto, H, Hong, S, Bhagwat, AS, Zhang, X, Cheng, X

Nucleic Acids Res. 2012
8407958 The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells

Neddermann, P, Jiricny, J

J. Biol. Chem. 1993
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
DNA N-glycosylase activity of TDG:(Ura:Gua)-dsDNA [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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