NTHL1 (hNTH1; endonuclease III-like protein 1) recognizes and binds 4,6-diamino-5-formamidopyrimidine (FapyA), an imidazole ring-opened adenine derivative (Luna et al. 2000, Hu et al. 2005). FapyA is formed during oxidative stress when hydroxyl radicals attack adenine, followed by one-electron reduction of the hydroxyl adduct radicals (Evans et al. 2004).
Luna, L, Bjørås, M, Hoff, E, Rognes, T, Seeberg, E
Hu, J, de Souza-Pinto, NC, Haraguchi, K, Hogue, BA, Jaruga, P, Greenberg, MM, Dizdaroglu, M, Bohr, VA
Evans, MD, Dizdaroglu, M, Cooke, MS
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