NTHL1 (hNTH1; endonuclease III-like protein 1) recognizes and binds 4,6-diamino-5-formamidopyrimidine (FapyA), an imidazole ring-opened adenine derivative (Luna et al. 2000, Hu et al. 2005). FapyA is formed during oxidative stress when hydroxyl radicals attack adenine, followed by one-electron reduction of the hydroxyl adduct radicals (Evans et al. 2004).
de Souza-Pinto, NC,