NTHL1 glycosylase mediated recognition and binding of formamidopyrimidine (FapyA)

Stable Identifier
R-HSA-110213
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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NTHL1 (hNTH1; endonuclease III-like protein 1) recognizes and binds 4,6-diamino-5-formamidopyrimidine (FapyA), an imidazole ring-opened adenine derivative (Luna et al. 2000, Hu et al. 2005). FapyA is formed during oxidative stress when hydroxyl radicals attack adenine, followed by one-electron reduction of the hydroxyl adduct radicals (Evans et al. 2004).

Literature References
PubMed ID Title Journal Year
10882850 Cell-cycle regulation, intracellular sorting and induced overexpression of the human NTH1 DNA glycosylase involved in removal of formamidopyrimidine residues from DNA

Luna, L, Bjørås, M, Hoff, E, Rognes, T, Seeberg, E

Mutat. Res. 2000
16221681 Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes

Hu, J, de Souza-Pinto, NC, Haraguchi, K, Hogue, BA, Jaruga, P, Greenberg, MM, Dizdaroglu, M, Bohr, VA

J. Biol. Chem. 2005
15341901 Oxidative DNA damage and disease: induction, repair and significance

Evans, MD, Dizdaroglu, M, Cooke, MS

Mutat. Res. 2004
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