NTHL1 glycosylase mediated recognition and binding of thymine glycol

Stable Identifier
R-HSA-110211
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NTHL1 glycosylase mediated recognition and binding of thymine glycol
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NTHL1 (hNTH1; endonuclease III-like protein 1) is a human ortholog of E. coli DNA repair enzyme Nth1. NTHL1 recognizes and binds thymine glycol, generated by thymine oxidation (Ikeda et al. 1998, Dizdaroglu et al. 1999, Myabe et al. 2002).

Literature References
PubMed ID Title Journal Year
12140329 Identification of 5-formyluracil DNA glycosylase activity of human hNTH1 protein

Miyabe, I, Zhang, QM, Kino, K, Sugiyama, H, Takao, M, Yasui, A, Yonei, S

Nucleic Acids Res. 2002
9705289 Purification and characterization of human NTH1, a homolog of Escherichia coli endonuclease III. Direct identification of Lys-212 as the active nucleophilic residue

Ikeda, S, Biswas, T, Roy, R, Izumi, T, Boldogh, I, Kurosky, A, Sarker, AH, Seki, S, Mitra, S

J. Biol. Chem. 1998
9890904 Excision of products of oxidative DNA base damage by human NTH1 protein

Dizdaroglu, M, Karahalil, B, Sentürker, S, Buckley, TJ, Roldán-Arjona, T

Biochemistry 1999
Participants
Input
Output
Participant Of
hasEvent
Authored
Matthews, L  (2004-02-03)
Reviewed
Borowiec, JA  (2014-12-22)
Created
Matthews, L  (2004-01-29)