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NTHL1 glycosylase mediated recognition and binding of cytosine glycol
Stable Identifier
R-HSA-110208
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Base-Excision Repair, AP Site Formation (Homo sapiens)
Depyrimidination (Homo sapiens)
Recognition and association of DNA glycosylase with site containing an affected pyrimidine (Homo sapiens)
NTHL1 glycosylase mediated recognition and binding of cytosine glycol (Homo sapiens)
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NTHL1 (hNTH1; endonuclease III-like protein 1) recognizes and binds cytosine glycol (5,6-dihydroxycytosine), a product of DNA damaging cytosine oxidation (Dizdaroglu et al. 1999).
Literature References
PubMed ID
Title
Journal
Year
9890904
Excision of products of oxidative DNA base damage by human NTH1 protein
Sentürker, S
,
Dizdaroglu, M
,
Buckley, TJ
,
Roldán-Arjona, T
,
Karahalil, B
Biochemistry
1999
Participants
Input
Cg-dsDNA [nucleoplasm]
(Homo sapiens)
NTHL1 [nucleoplasm]
(Homo sapiens)
Output
NTHL1:Cg-dsDNA [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Recognition and association of DNA glycosylase with site containing an affected pyrimidine (Homo sapiens)
Authored
Matthews, L (2004-02-03)
Reviewed
Borowiec, JA (2014-12-22)
Created
Matthews, L (2004-01-29)
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