SMUG1 glycosylase mediated recognition and binding of uracil in DNA

Stable Identifier
R-HSA-110164
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SMUG1 glycosylase mediated recognition and binding of uracil in DNA
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SMUG1, a single-strand selective monofunctional uracil DNA glycosylase, recognizes and binds uracil residues in the DNA. SMUG1 shows a preference for single-strand DNA, although it also recognizes A:U and G:U pairs in double-strand DNA (Haushalter et al. 1999, Masaoka et al. 2003).
Literature References
PubMed ID Title Journal Year
12718543 Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions

Masaoka, A, Matsubara, M, Hasegawa, R, Tanaka, T, Kurisu, S, Terato, H, Ohyama, Y, Karino, N, Matsuda, A, Ide, H

Biochemistry 2003
10074426 Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors

Haushalter, KA, Todd Stukenberg, MW, Kirschner, MW, Verdine, GL

Curr. Biol. 1999
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Authored
Matthews, L  (2004-02-03)
Reviewed
Borowiec, JA  (2014-12-22)
Created
Matthews, L  (2004-01-29)
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