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TDG glycosylase mediated recognition and binding of an uracil opposite to a guanine
Stable Identifier
R-HSA-110159
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Base-Excision Repair, AP Site Formation (Homo sapiens)
Depyrimidination (Homo sapiens)
Recognition and association of DNA glycosylase with site containing an affected pyrimidine (Homo sapiens)
TDG glycosylase mediated recognition and binding of an uracil opposite to a guanine (Homo sapiens)
General
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TDG, a G/T mismatch-specific thymine DNA glycosylase, recognizes and binds uracil mispaired with guanine. G:U mispairs occur after cytosine undergoes spontaneous deamination and converts to uracil (Neddermann and Jiricny 1993, Hashimoto et al. 2012).
Literature References
PubMed ID
Title
Journal
Year
8407958
The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells
Jiricny, J
,
Neddermann, P
J. Biol. Chem.
1993
22962365
Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation
Hong, S
,
Hashimoto, H
,
Zhang, X
,
Bhagwat, AS
,
Cheng, X
Nucleic Acids Res.
2012
Participants
Input
(Ura:Gua)-dsDNA [nucleoplasm]
(Homo sapiens)
TDG [nucleoplasm]
(Homo sapiens)
Output
TDG:(Ura:Gua)-dsDNA [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Recognition and association of DNA glycosylase with site containing an affected pyrimidine (Homo sapiens)
Authored
Matthews, L (2004-02-03)
Reviewed
Borowiec, JA (2014-12-22)
Created
Matthews, L (2004-01-29)
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