UNG glycosylase mediated recognition and binding of an uracil opposite to a guanine

Stable Identifier
R-HSA-110156
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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UNG glycosylase mediated recognition and binding of an uracil opposite to a guanine
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UNG, a uracil DNA glycosylase, recognizes DNA damage that converts cytosine to uracil through deamination, creating a U:G base pair. UNG also recognizes U:A base pairs created when dUMP is misincorporated during DNA synthesis. The UNG transcription isoform 2, labeled as UNG-1 and also known as UDG2, functions in the nucleus, while the UNG transcription isoform 1, which is not annotated here, functions in mitochondria (Parikh et al. 1998).
Literature References
PubMed ID Title Journal Year
9724657 Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA

Tainer, JA, Bharati, S, Krokan, HE, Mol, CD, Slupphaug, G, Parikh, SS

EMBO J 1998
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Authored
Matthews, L  (2004-02-03)
Reviewed
Borowiec, JA  (2014-12-22)
Created
Matthews, L  (2004-01-29)
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