p-S218,S222-MAP2K1 [cytosol]

Stable Identifier
R-HSA-109837
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
p-S218,222-MEK1, Dual specificity mitogen-activated protein kinase kinase 1(phosphorylated), MAP kinase kinase 1(phosphorylated), p-S218,222-MAPKK 1, ERK activator kinase 1(phosphorylated), MAPK/ERK kinase 1
p-S218,S222-MAP2K1 [cytosol] icon
Locations in the PathwayBrowser for interactor UniProt:P46937 YAP1
External Reference Information
External Reference
Gene Names
MAP2K1, MEK1, PRKMK1
Chain
chain:1-393
Other Identifiers
0001740347
1130_at
11717291_a_at
11749555_a_at
11757478_s_at
16802190
1844_s_at
202670_at
3092255
3092256
3092263
3092264
3598663
3598664
3598670
3598671
3598672
3598673
3598688
3598690
3598691
3598692
3598696
3598697
3598700
3598701
3598702
5604
7984319
A_23_P20248
GE57608
GO:0000003
GO:0000165
GO:0000166
GO:0000187
GO:0000278
GO:0000902
GO:0002376
GO:0003674
GO:0004672
GO:0004674
GO:0004708
GO:0004712
GO:0004713
GO:0005078
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005739
GO:0005768
GO:0005769
GO:0005770
GO:0005783
GO:0005794
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005925
GO:0006464
GO:0006468
GO:0006810
GO:0006935
GO:0006950
GO:0007049
GO:0007050
GO:0007165
GO:0007346
GO:0007507
GO:0007568
GO:0008022
GO:0008150
GO:0008283
GO:0008285
GO:0009058
GO:0009790
GO:0010628
GO:0010629
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018107
GO:0018108
GO:0019899
GO:0021697
GO:0023014
GO:0030154
GO:0030182
GO:0030216
GO:0030234
GO:0030674
GO:0030878
GO:0031098
GO:0031410
GO:0032147
GO:0032872
GO:0034641
GO:0040011
GO:0043167
GO:0043226
GO:0043539
GO:0045597
GO:0045893
GO:0047485
GO:0048538
GO:0048646
GO:0048679
GO:0048856
GO:0048870
GO:0050772
GO:0060020
GO:0060324
GO:0060425
GO:0060440
GO:0060502
GO:0060674
GO:0060711
GO:0070371
GO:0070374
GO:0071902
GO:0090170
GO:0090398
GO:0097110
GO:1903800
GO:2000641
Hs.3446.0.A2_3p_at
ILMN_1694240
L05624_s_at
L11284_at
PH_hs_0022483
TC15000613.hg
Participant Of
Other forms of this molecule
Inferred To
Modified Residues
Name
O-phospho-L-serine at 218
Coordinate
218
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 222
Coordinate
222
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
ZINC - Investigational
ZINC - Metabolites
IntEnz
GeneCards
Orphanet
ZINC - Predictions - Purchasable
Interactors (23)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P15056 BRAF  68 0.977 60
 UniProt:P04049 RAF1  54 0.955 37
 UniProt:P10398 ARAF  4 0.758 7
 UniProt:Q8IVT5 KSR1  5 0.725 9
 UniProt:P31946 YWHAB  1 0.643 4
 UniProt:P28482 MAPK1  18 0.609 2
 UniProt:Q8WWU5-7 TCP11      0.556 3
 UniProt:Q8N9N5-2 BANP      0.556 3
 UniProt:Q9H8W4 PKHF2      0.556 3
 UniProt:P46937 YAP1  7 0.556 3
 UniProt:Q8N9N5 BANP  1 0.556 3
 UniProt:Q9Y297 BTRC  2 0.556 3
 UniProt:Q04917 YWHAH  1 0.527 3
 UniProt:P61981 YWHAG  1 0.527 3
 UniProt:P63104 YWHAZ  2 0.527 4
 UniProt:P62258 YWHAE  1 0.527 3
 UniProt:Q86Y07 VRK2      0.524 2
 UniProt:Q61097  5 0.508 2
 UniProt:Q13526 PIN1  2 0.508 5
 UniProt:P27361 MAPK3  6 0.499 2
 UniProt:Q86Y07-1 VRK2      0.499 2
 UniProt:Q96S96 PEBP4      0.462 3
 UniProt:O75832 PSMD10  2 0.462 2
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