Reactome | MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2

MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2

Stable Identifier

R-HSA-109823

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2

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At the beginning of this reaction, 4 molecules of 'ATP', and 1 molecule of 'GRB2:SOS:IRS-P' are present. At the end of this reaction, 1 molecule of 'GRB2:IRS-P', 1 molecule of 'phospho-SOS', and 4 molecules of 'ADP' are present.

This reaction takes place on the 'internal side of plasma membrane' and is mediated by the 'kinase activity' of 'ERK1'.

Literature References

PubMed ID	Title	Journal	Year
8816480	Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2. Corbalan-Garcia, S, Yang, SS, Degenhardt, KR	Mol Cell Biol	1996
7739560	Insulin-stimulated disassociation of the SOS-Grb2 complex. Waters, SB, Yamauchi, K, Pessin, JE	Mol Cell Biol	1995