Reactome | GTF2A1(1-274) [nucleoplasm]

GTF2A1(1-274) [nucleoplasm]

Stable Identifier

R-HSA-109767

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcription Factor IIA alpha chain - p35

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Nuclear Receptors (Homo sapiens)
  - ESR-mediated signaling (Homo sapiens)
    - Estrogen-dependent gene expression (Homo sapiens)
      - CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Homo sapiens)
        
        CARM1:TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TFIIA [nucleoplasm] (Homo sapiens)
        
        GTF2A1(1-274) [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TFIIA [nucleoplasm] (Homo sapiens)
        
        GTF2A1(1-274) [nucleoplasm] (Homo sapiens)
      - Estrogen-responsive TFF1 gene expression (Homo sapiens)
        
        ESR1:estrogen:TFF1gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1:HATs [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1 [nucleoplasm] (Homo sapiens)
        
        CARM1:TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TFIIA [nucleoplasm] (Homo sapiens)
        
        GTF2A1(1-274) [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:DDX5:TBP:TFIIA:PRMT1:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TFIIA [nucleoplasm] (Homo sapiens)
        
        GTF2A1(1-274) [nucleoplasm] (Homo sapiens)
      - Histone acetyltransferases are recruited to the TFF1 gene (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1 [nucleoplasm] (Homo sapiens)
        
        CARM1:TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TFIIA [nucleoplasm] (Homo sapiens)
        
        GTF2A1(1-274) [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:DDX5:TBP:TFIIA:PRMT1:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TFIIA [nucleoplasm] (Homo sapiens)
        
        GTF2A1(1-274) [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1:HATs [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1 [nucleoplasm] (Homo sapiens)
        
        CARM1:TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TFIIA [nucleoplasm] (Homo sapiens)
        
        GTF2A1(1-274) [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:DDX5:TBP:TFIIA:PRMT1:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TFIIA [nucleoplasm] (Homo sapiens)
        
        GTF2A1(1-274) [nucleoplasm] (Homo sapiens)
      - PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:DDX5:TBP:TFIIA:PRMT1:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TFIIA [nucleoplasm] (Homo sapiens)
        
        GTF2A1(1-274) [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TFIIA [nucleoplasm] (Homo sapiens)
        
        GTF2A1(1-274) [nucleoplasm] (Homo sapiens)
      - TBP and TFIIA bind TATA box on ESR1:estrogen bound TFF1 gene promoter (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TFIIA [nucleoplasm] (Homo sapiens)
        
        GTF2A1(1-274) [nucleoplasm] (Homo sapiens)
        
        TFIIA [nucleoplasm] (Homo sapiens)
        
        GTF2A1(1-274) [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P52655 GTF2A1

Gene Names

GTF2A1, TF2A1

Chain

initiator methionine:, chain:2-376, chain:2-274, chain:275-376

Reference Genes

BioGPS Gene:2957 GTF2A1

COSMIC (genes):GTF2A1 GTF2A1

CTD Gene:2957 GTF2A1

dbSNP Gene:2957 GTF2A1

ENSEMBL:ENSG00000165417 GTF2A1

ENSEMBL_homo_sapiens_GENE:ENSG00000165417.12 GTF2A1

HGNC:4646 GTF2A1

KEGG Gene (Homo sapiens):2957 GTF2A1

Monarch:2957 GTF2A1

NCBI Gene:2957 GTF2A1

OMIM:600520 GTF2A1

UCSC:P52655 GTF2A1

Reference Transcript

Other Identifiers

11740965_a_at

16795351

206521_PM_s_at

206521_s_at

225433_PM_at

225433_at

2957

313_at

35495_at

3574073

3574075

3574076

3574077

3574078

3574079

3574080

3574081

3574084

3574085

3574086

3574087

3574088

3574090

3574091

3574092

3574093

3574097

3574103

3574104

3574105

3574106

3574107

3574108

44152_at

61385_at

63087_at

7980523

80266_at

A_23_P65609

A_23_P65615

A_24_P201936

GE57095

GE86329

GE86330

GO:0000979

GO:0001091

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0005669

GO:0005672

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006366

GO:0006367

GO:0016251

GO:0017025

GO:0043226

GO:0045944

GO:0046982

GO:0051123

GO:0060261

GO:0061629

GO:0065003

GO:0097550

GO:0140223

HMNXSV003041518

Hs.299542.0.S1_3p_at

ILMN_1725247

ILMN_1732040

ILMN_2249552

PH_hs_0015446

PH_hs_0026727

PH_hs_0037756

TC14001368.hg

TC14002101.hg

g7706734_3p_a_at

Participates

as a component of

TFIIA [nucleoplasm] (Homo sapiens)

Other forms of this molecule

GTF2A1(275-376) [nucleoplasm]

Inferred To

GTF2A1(1-274) [nucleoplasm] (Mus musculus)

GTF2A1(1-274) [nucleoplasm] (Rattus norvegicus)

gtf2a1 [nucleoplasm] (Danio rerio)

gtf2a1 [nucleoplasm] (Dictyostelium discoideum)

toa1 [nucleoplasm] (Schizosaccharomyces pombe)

GTF2A1 [nucleoplasm] (Bos taurus)

GTF2A1 [nucleoplasm] (Canis familiaris)

GTF2A1 [nucleoplasm] (Gallus gallus)

GTF2A1 [nucleoplasm] (Sus scrofa)

TOA1 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of GTF2A1(1-274) [nucleoplasm] (Xenopus tropicalis)

TfIIA-L [nucleoplasm] (Drosophila melanogaster)

pqn-51 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_963889.1, NP_001265869.1, NP_056943.1

OpenTargets

ENSG00000165417

GeneCards

P52655

HPA

ENSG00000165417-GTF2A1

Ensembl

ENSP00000409492, ENSP00000452454, ENST00000553612, ENST00000434192, ENSG00000165417

PRO

P52655

Pharos - Targets

P52655

PDB

5IY7, 5IY6, 8WAK, 5IYD, 7ZWD, 8S5N, 7EG9, 5IYC, 8BVW, 1NVP, 8WAS, 7ZX8, 8BZ1, 7NVS, 7ZX7, 7EG7, 8S52, 5FUR, 8BYQ, 7EGJ, 8WAL, 8WAQ, 7NW0, 5M4S, 7LBM, 7NVZ, 7EGI, 7ZXE, 8WAP, 7NVY, 7ZWC, 8WAO, 7EGD, 7EGC, 7NVU, 7EG8, 8GXS, 5IYA, 8WAN, 8WAR, 5IYB, 7EGB, 6O9L, 7NVT, 8GXQ, 5IY9, 5IY8, 7EDX, 8S51, 7NVR, 7EGA, 6MZM

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P20226 TBP	1	TBP [nucleoplasm] (R-HSA-83718)	0.744	5
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.556	3
UniProt:Q96CA5 BIRC7	1	BIRC7 [cytosol] (R-HSA-50855)	0.556	3
UniProt:O15357 INPPL1	1	INPPL1 [cytosol] (R-HSA-913354)	0.527	2

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