Reactome | CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]

CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]

Stable Identifier

R-HSA-109291

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

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CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]

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5'-nucleotidase (NT5E) associated with the plasma membrane catalyzes the reactions of extracellular CMP, TMP, or UMP with H2O to yield the corresponding nucleoside and orthophosphate. The active enzyme is a glycolipid-anchored dimer (Misumi et al. 1990; Thompson et al. 1987; Zimmerman 1992)

Literature References

PubMed ID	Title	Journal	Year
2129526	Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form Misumi, Y, Ogata, S, Ohkubo, K, Hirose, S, Ikehara, Y	Eur J Biochem	1990
2826576	Distribution of ecto-5'-nucleotidase on subsets of human T and B lymphocytes as detected by indirect immunofluorescence using goat antibodies Thompson, LF, Ruedi, JM, Low, MG, Clement, LT	J. Immunol.	1987
16377327	The importance of having a mentor, and how to find one Stone, CD	Gastrointest. Endosc.	2006