Reactome | NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP

NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP

Stable Identifier

R-HSA-109278

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

AMP + H2O => adenosine + phosphate, dAMP + H2O => 2'-deoxyadenosine + phosphate, GMP + H2O => guanosine + phosphate, IMP + H2O => inosine + phosphate

ReviewStatus

5/5

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5'-nucleotidase (NT5E) associated with the plasma membrane catalyzes the reactions of extracellular AMP, dAMP, GMP, or IMP with H2O to yield the corresponding nucleoside and orthophosphate. The active enzyme is a glycolipid-anchored dimer (Misumi et al. 1990; Thompson et al. 1987; Zimmerman 1992)

Literature References

PubMed ID	Title	Journal	Year
1637327	5'-nucleotidase: molecular structure and functional aspects Zimmermann, H	Biochem J	1992
2129526	Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form Misumi, Y, Ogata, S, Ohkubo, K, Hirose, S, Ikehara, Y	Eur J Biochem	1990
3036115	Purification of 5'-nucleotidase from human placenta after release from plasma membranes by phosphatidylinositol-specific phospholipase C Thompson, LF, Ruedi, JM, Low, MG	Biochem Biophys Res Commun	1987